七氟烷和丙泊酚对老年患者腹腔镜胆囊切除术后认知功能的影响研究

发布时间：2018-08-06 17:58

【摘要】：目的探讨七氟烷和丙泊酚对老年患者腹腔镜胆囊切除术后认知功能的影响。方法选择2016年3月至2016年9月择期行腹腔镜胆囊切除的患者共60例,分为七氟醚组(S组)和丙泊酚组(P组),每组30例。比较两组患者术后简易认知功能筛查表(MMSE)评分和术后认知功能障碍(POCD)发生率。结果 T_0时,P组和S组患者的MMSE评分比较差异无统计学意义(P0.05);T_1和T_2时,S组患者的MMSE值明显低于P组,且T_1时S组患者的POCD发生率明显高于P组;T_3时,两组患者MMSE评分、POCD发生率比较差异无统计学意义(P0.05)。S组患者在T_1、T_2、T_3时的MMSE评分均较T_0明显降低(P0.05);P组患者在T_1、T_2时的MMSE评分均较T_0明显降低(P0.05),在T3时逐渐恢复。结论与丙泊酚相比,七氟烷对老年患者POCD发生的影响更加显著且持久。
[Abstract]:Objective to investigate the effect of sevoflurane and propofol on cognitive function after laparoscopic cholecystectomy in elderly patients. Methods A total of 60 patients undergoing laparoscopic cholecystectomy from March 2016 to September 2016 were divided into sevoflurane group (group S) and propofol group (group P) with 30 cases in each group. The (MMSE) score of simple cognitive function screening form and the incidence of postoperative (POCD) of cognitive dysfunction were compared between the two groups. Results there was no significant difference in the MMSE scores between the patients in group P and group S (P0.05) the MMSE value of patients in group S was significantly lower than that in group P, and the incidence of POCD in group S at T 1 was significantly higher than that in group P (P < 0.05), and the incidence of POCD in group S at T 1 was significantly higher than that in group S (P < 0.05), and the incidence of POCD in group S at T 1 was significantly higher than that in group T 3. There was no significant difference in the incidence rate of MMSE score and POCD between the two groups (P0.05). The MMSE scores of the patients in the group S were significantly lower than those in the group T0 (P0.05), and the MMSE scores of the patients in the group P were significantly lower than those of the patients at the time of T0 (P0.05), and gradually recovered at T3. Conclusion compared with propofol, sevoflurane has a more significant and lasting effect on the occurrence of POCD in elderly patients.
【作者单位】：重庆市第五人民医院麻醉科;
【基金】：重庆市南岸区科技攻关计划基金资助项目(201620)
【分类号】：R614

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