仙灵骨葆结合经皮球囊扩张椎体后凸成形术治疗老年骨质疏松椎体压缩性骨折的效果

发布时间：2018-08-09 15:35

【摘要】：目的探讨仙灵骨葆胶囊结合经皮球囊扩张椎体后凸成形术(PKP)治疗老年骨质疏松椎体压缩性骨折(OVF)的临床疗效。方法选取因OVF行经皮球囊扩张椎体后凸成形术的患者共90例,随机分为处理组和对照组,处理组在术后持续服用仙灵骨葆胶囊、钙剂和骨化三醇6个月,对照组患者术后仅服用钙剂和骨化三醇,对比两组患者术前、术后1个月、术后3个月和术后6个月的JOA评分、VAS评分和骨密度数据。结果治疗前两组患者的JOA评分差异无统计学意义,在治疗后1个月、3个月和6个月,处理组的JOA评分均高于对照组,差异具有统计学意义(P0.05),处理组和对照组患者治疗后1个月、3个月和6个月的VAS评分均较治疗前下降(P0.05)。但两组患者在治疗前、治疗后1个月、3个月和6个月的VAS评分对比,差异均无统计学意义(P0.05)。两组在治疗前和术后1个月骨密度差异均无统计学意义,处理组在治疗后3个月和6个月,骨密度T值均小于对照组,差异具有统计学意义(P0.05)。结论仙灵骨葆胶囊结合PKP治疗老年OVF可促进患者术后腰部功能的恢复,提高腰椎骨密度,可作为PKP治疗老年OVF术后行抗骨质疏松的联合治疗。
[Abstract]:Objective to investigate the clinical effect of Xianling Gubao capsule combined with percutaneous balloon kyphoplasty (PKP) in the treatment of senile osteoporotic vertebral compression fracture (OVF). Methods 90 cases of kyphoplasty were randomly divided into two groups: treatment group and control group. The treatment group took Xianling Gubao capsule, calcium and calcitriol for 6 months after operation. The patients in the control group only took calcium and ossification triol after operation. The JOA scores and bone mineral density were compared between the two groups before operation, 1 month after operation, 3 months after operation and 6 months after operation. Results there was no significant difference in JOA scores between the two groups before treatment. The JOA scores in the treatment group were higher than those in the control group at 1 month, 3 months and 6 months after treatment. The difference was statistically significant (P0.05). The VAS scores of the treatment group and the control group were decreased after 1 month, 3 months and 6 months (P0.05). However, there was no significant difference in VAS scores between the two groups before treatment, 1 month, 3 months and 6 months after treatment (P0.05). There was no significant difference in BMD between the two groups before and 1 month after treatment. The T value of BMD in the treatment group was lower than that in the control group 3 and 6 months after treatment (P0.05). Conclusion Xianling Gubao capsule combined with PKP can promote the recovery of lumbar function and increase bone mineral density of lumbar vertebrae in elderly patients with OVF. It can be used as a combined therapy of anti-osteoporosis after PKP in elderly OVF patients.
【作者单位】：阳江市人民医院药学部;
【分类号】：R687.3;R580

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