细胞外基质材料在骨组织工程中的研究进展
发布时间：2018-08-17 16:13
【摘要】：由疾病、外部创伤等原因引起的大骨骼缺损的治疗需要通过骨移植手术,寻找安全易得的替代骨已经成为临床上的重要课题,近年来快速发展的组织工程骨为解决这一难题提供了一种新的途径。支架材料作为组织工程的核心要素,其表面性状、结构,机械性能和生物学性能均能调控细胞的各种生命活动和体内组织的修复再生。细胞外基质由于其天然性、低免疫排斥性和优异的生物相容性等特点,已被广泛用作再生医学的支架材料。通过回顾近些年来细胞外基质材料在骨组织工程中的应用,阐述多种细胞外基质材料的构建修饰方法及其体外、体内的生物学效应,并对其在骨再生领域的应用前景进行展望。
[Abstract]:The treatment of large bone defects caused by diseases and external trauma has become an important issue in clinical practice. The rapid development of tissue engineering bone in recent years provides a new way to solve this problem. As the core element of tissue engineering, scaffold material can regulate all kinds of life activities of cells and repair and regeneration of tissues in vivo, such as surface properties, structure, mechanical properties and biological properties. Extracellular matrix (ECM) has been widely used as scaffold material for regenerative medicine due to its natural nature, low immune rejection and excellent biocompatibility. By reviewing the applications of extracellular matrix materials in bone tissue engineering in recent years, the construction and modification methods of various extracellular matrix materials and their biological effects in vitro and in vivo were reviewed, and the prospect of their application in bone regeneration was also prospected.
【作者单位】： 宁波大学医学院浙江省病理生理学技术研究重点实验室;宁波市医学科学研究所;
【基金】：国家自然科学基金青年基金(31300800) 宁波市自然科学基金(2014A610238);宁波市自然科学基金(2014A610220)
【分类号】：R318.08;R68
[Abstract]:The treatment of large bone defects caused by diseases and external trauma has become an important issue in clinical practice. The rapid development of tissue engineering bone in recent years provides a new way to solve this problem. As the core element of tissue engineering, scaffold material can regulate all kinds of life activities of cells and repair and regeneration of tissues in vivo, such as surface properties, structure, mechanical properties and biological properties. Extracellular matrix (ECM) has been widely used as scaffold material for regenerative medicine due to its natural nature, low immune rejection and excellent biocompatibility. By reviewing the applications of extracellular matrix materials in bone tissue engineering in recent years, the construction and modification methods of various extracellular matrix materials and their biological effects in vitro and in vivo were reviewed, and the prospect of their application in bone regeneration was also prospected.
【作者单位】： 宁波大学医学院浙江省病理生理学技术研究重点实验室;宁波市医学科学研究所;
【基金】：国家自然科学基金青年基金(31300800) 宁波市自然科学基金(2014A610238);宁波市自然科学基金(2014A610220)
【分类号】：R318.08;R68
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