抗菌药物与手术治疗单纯性急性阑尾炎的系统评价
发布时间：2018-08-20 19:44
【摘要】：目的评价抗菌药物保守治疗与阑尾切除术治疗单纯性急性阑尾炎(AA)的疗效与安全性。方法计算机检索中国生物医学文献数据库(CBM,1978年至2015年6月)、相关期刊论文(CNKI,1979年至2015年6月)、Medline(1950年至2015年6月)、Pubmed(1950年至2015年6月)、Embase(1970年至2015年6月)和Cochrane图书馆(2015年第2期),收集抗菌药物保守治疗与阑尾切除术治疗单纯性AA的随机对照试验(RCT),按照Cochrane系统评价方法,由两名研究者独立地对符合纳入标准的试验进行资料提取,并对纳入文献进行质量评估和对提取的有效数据进行Meta分析。结果纳入6个RCTs,共1 510例单纯性AA患者符合纳入标准,其中使用抗菌药物治疗的有767例,采用阑尾切除术治疗的有743例。与手术治疗比较,抗菌药物保守治疗的有效率降低了25.00%(RD=-0.25,95%CI:-0.35~-0.14),复发率升高48.43倍(OR=48.43,95%CI:16.94~138.44),劳动力丧失时间缩短1.52d(MD=-1.52,95%CI:-3.02~-0.02),但在并发症的发生率(RD=-0.06,95%CI:-0.15~0.03)、疼痛时间(MD=-0.76,95%CI:-3.31~1.79)、住院时间(MD=4.60,95%CI:-0.89~10.09)、病假时间(MD=-2.39,95%CI:-5.62~0.84)方面两种治疗方法比较,差异无统计学意义(P0.05)。结论阑尾切除术可能仍是治疗单纯性AA的金标准方法。
[Abstract]:Objective to evaluate the efficacy and safety of conservative antimicrobial therapy and appendectomy in the treatment of simple acute appendicitis (AA). Methods the Chinese biomedical literature database (CBM, 1978-June 2015), the China Journal Full-text Database (CNKI, 1979-June 2015), the Medline (1950-June 2015) and the Cochrane Library (1970-June 2015) were searched by computer. Phase 2), (RCT), a randomized controlled trial of conservative antimicrobial therapy and appendectomy for simple AA, was evaluated according to the Cochrane system. The data were extracted by two researchers independently, and the quality of the literature was evaluated and the valid data were analyzed by Meta. Results A total of 1 510 patients with simple AA were included in 6 RCTs, including 767 patients treated with antimicrobial agents and 743 patients treated with appendectomy. Compared with surgical treatment, 鎶楄弻鑽墿淇濆畧娌荤枟鐨勬湁鏁堢巼闄嶄綆浜，
本文编号：2194783
[Abstract]:Objective to evaluate the efficacy and safety of conservative antimicrobial therapy and appendectomy in the treatment of simple acute appendicitis (AA). Methods the Chinese biomedical literature database (CBM, 1978-June 2015), the China Journal Full-text Database (CNKI, 1979-June 2015), the Medline (1950-June 2015) and the Cochrane Library (1970-June 2015) were searched by computer. Phase 2), (RCT), a randomized controlled trial of conservative antimicrobial therapy and appendectomy for simple AA, was evaluated according to the Cochrane system. The data were extracted by two researchers independently, and the quality of the literature was evaluated and the valid data were analyzed by Meta. Results A total of 1 510 patients with simple AA were included in 6 RCTs, including 767 patients treated with antimicrobial agents and 743 patients treated with appendectomy. Compared with surgical treatment, 鎶楄弻鑽墿淇濆畧娌荤枟鐨勬湁鏁堢巼闄嶄綆浜，
本文编号：2194783
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