血浆和关节液趋化因子12的表达水平与膝骨关节炎严重程度的相关性

发布时间：2018-08-21 07:25

【摘要】：目的探讨血浆和关节液趋化因子12(CXCL12)的表达水平与膝骨关节炎严重程度的相关性。方法选取膝骨关节炎患者80例(观察组)和膝关节健康的参与者80例(对照组),所有患者根据骨关节炎Kellgren-Lawrence标准进行影像学分级(K-L分级)并进行膝关节WOMAC评分,分别对比两组血浆CXCL12水平,并根据膝骨关节炎患者的血浆和关节液CXCL12水平与K-L分级、膝关节WOMAC评分进行相关性分析。结果观察组CXCL12水平显著高于对照组,差异有统计学意义(Z=-10.699,P0.01)。放射学K-L分级与血浆CXCL12水平和关节液CXCL12水平均呈正相关(r=0.854,P0.05;r=0.705,P0.05);血浆CXCL12水平与膝关节WOMAC评分呈正相关(r=0.767,P0.05),关节液CXCL12水平与膝关节WOMAC评分同样呈正相关(r=0.663,P0.05)。结论血浆和关节液CXCL12水平与膝骨关节炎的严重程度呈正相关,可作为评估膝骨关节炎的严重程度的生物标记物。
[Abstract]:Objective to investigate the relationship between the expression of chemokine 12 (CXCL12) in plasma and joint fluid and the severity of knee osteoarthritis. Methods Eighty patients with knee osteoarthritis (observation group) and 80 healthy knee joint participants (control group) were selected. According to the Kellgren-Lawrence criteria of osteoarthritis, all the patients were assessed with imaging grade (K-L grade) and knee joint WOMAC score. The plasma CXCL12 levels were compared between the two groups, and the correlation analysis was carried out according to the levels of CXCL12 in plasma and joint fluid, K-L grade and WOMAC score of knee joint in patients with knee osteoarthritis. Results the level of CXCL12 in the observation group was significantly higher than that in the control group (P 0.01). Radiologic K-L grade was positively correlated with plasma CXCL12 level and CXCL12 level in articular fluid (P 0.05), plasma CXCL12 level was positively correlated with WOMAC score of knee joint (r 0.767P 0.05), and CXCL12 level of articular fluid was also positively correlated with WOMAC score of knee joint (r 0.663P 0.05). Conclusion Plasma and fluid CXCL12 levels are positively correlated with the severity of knee osteoarthritis and can be used as biomarkers to evaluate the severity of knee osteoarthritis.
【作者单位】：揭阳市人民医院骨一科;
【分类号】：R684.3

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