基于患者特征的颅内动脉瘤破裂相关危险因素研究

发布时间：2018-08-21 12:11

【摘要】：目的：探讨诱发颅内未破裂动脉瘤发生破裂的危险因素,为更好的对颅内动脉瘤的破裂预测及临床管理提供依据。方法：回顾性研究浙江大学附属第一医院2011年1月至2014年12月确诊为颅内动脉瘤的患者,根据动脉瘤破裂与否分为破裂组(n=403)和未破裂组(n=285),从患者的年龄、性别、高血压病史、糖尿病史、高脂血症史、吸烟史、饮酒史等方面进行分析,并将年龄、女性及高脂血症类型进行分级分析,得出颅内动脉瘤破裂与这些因素之间的关系。结果：对两组临床资料的各变量单因素分析研究显示,高血压病(P0.001)、女性(P=0.027)、小于60岁(P0.001)与颅内动脉瘤的破裂有显著相关性,而与之相反,糖尿病(P0.001)、高脂血症(P0.001)是颅内动脉瘤破裂的保护因素；多因素logistics回归分析结果与单因素分析结果一致,高血压病、女性、小于60岁是动脉瘤破裂的独立危险因素,而糖尿病、高脂血症能降低动脉瘤破裂风险。结论：颅内动脉瘤破裂好发于40-60岁,高血压病、女性是颅内动脉瘤发生破裂的危险因素,糖尿病、高脂血症患者颅内动脉瘤破裂风险较低。对40-60岁的中年女性,尤其是患有高血压病的颅内动脉瘤患者,更倾向于手术干预。
[Abstract]:Objective: to explore the risk factors of ruptured intracranial unruptured aneurysms and to provide evidence for better prediction and clinical management of intracranial aneurysms. Methods: the patients diagnosed as intracranial aneurysms in the first affiliated Hospital of Zhejiang University from January 2011 to December 2014 were divided into two groups according to whether the aneurysm was ruptured or not. The history of hypertension, diabetes, hyperlipidemia, smoking and drinking were analyzed, and age, female and type of hyperlipidemia were analyzed, and the relationship between intracranial aneurysm rupture and these factors was obtained. Results: univariate analysis of the two groups of clinical data showed that hypertension (P0.001), female (P0. 027), younger than 60 years (P0. 001) were significantly correlated with the rupture of intracranial aneurysm. Diabetes mellitus (P0. 001), hyperlipidemia (P0. 001) were the protective factors of intracranial aneurysm rupture, and the results of multivariate logistics regression analysis were consistent with the results of univariate analysis. Hypertension, female, under 60 years old were independent risk factors of aneurysm rupture, while diabetes, Hyperlipidemia can reduce the risk of aneurysm rupture. Conclusion: intracranial aneurysm rupture is common in 40-60 years old, hypertension, female is the risk factor of intracranial aneurysm rupture, diabetes mellitus, hyperlipidemia patients have a lower risk of intracranial aneurysm rupture. Middle-aged women aged 40-60, especially intracranial aneurysms with hypertension, prefer surgical intervention.
【学位授予单位】：浙江大学
【学位级别】：博士
【学位授予年份】：2015
【分类号】：R651.1

【相似文献】