骨科择期清洁切口手术3种头孢菌素预防性应用临床随机研究

发布时间：2018-09-01 14:16

【摘要】：目的:评估骨科择期清洁切口手术预防性使用头孢硫脒、头孢唑林与头孢呋辛的有效性与安全性。方法:这项研究是我院2015年1月-2016年2月一项骨科择期清洁切口手术随机、开放性的临床对比研究。330名患者被纳入研究,随机分为头孢硫脒治疗组(A组)、头孢唑林治疗组(B组)和头孢呋辛治疗组(C组),术前、术后静脉滴注预防使用。三组均随访30d,使用手术部位感染的结果标准统计分析。结果:头孢硫脒治疗组(A组)浅表手术部位感染发生率为6.36%(1.73~10.9995%CI),头孢唑林治疗组(B组)浅表手术部位感染发生率为2.78%(0.32~5.88 95%CI)与头孢呋辛治疗组(C组)浅表手术部位感染发生率为3.57%(0.13~7.01 95%CI)。结论:骨科择期清洁切口手术预防手术部位的感染,头孢硫脒、头孢唑林、头孢呋辛之间的差异没有统计学意义(P=0.399)。
[Abstract]:Objective: to evaluate the efficacy and safety of prophylactic use of cefathiamidine, cefazolin and cefuroxime in elective open incision surgery in orthopaedic department. Methods: this study was conducted in our hospital from January 2015 to February 2016, a randomized, open clinical comparative study of .330 patients undergoing elective orthopedic incision surgery. They were randomly divided into cefathiamidine group (group A), cefazolin group (group B) and cefuroxime treatment group (group C). All the three groups were followed up for 30 days and the results of surgical site infection were statistically analyzed. Results: the incidence of superficial site infection was 6.36% (1.73~10.9995%CI) in group A, 2.78% (0.32 95%CI) in group B and 3.57% (0.137.01 95%CI) in group C. Conclusion: there was no significant difference in infection, cefathiamidine, cefazolin and cefuroxime between elective clean incision in orthopaedic department (P0. 399).
【作者单位】：广西梧州市中医医院临床药学科;广西梧州市中医医院骨伤科;广西梧州市中医医院;广西玉林市第二人民医院药剂科;广西梧州市中医医院手术室;
【基金】：广西壮族自治区卫生和计划生育委员会自筹经费科研课题项目(编号:Z2016370)
【分类号】：R687

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