氨甲环酸局部注射对初次单侧全膝关节置换术后失血量的影响
发布时间：2018-09-02 09:58
【摘要】：目的探讨氨甲环酸局部注射对初次单侧全膝关节置换术后失血量的影响。方法采用随机对照研究2013年12月-2016年08月在湖南省人民医院关节外科因骨关节炎行单侧初次关节置换术的60例患者,根据在关节腔关闭之前,关节囊局部是否注射氨甲环酸进行随机分组,分为实验组和对照组,各30例。实验组:在关节腔关闭之前,关节囊局部注射10 ml(1.0 g)氨甲环酸并放置高负压引流瓶;对照组:在关节腔关闭之前,关节囊囊壁周围局部注射10 ml生理盐水,同样放置高负压引流瓶。记录两组患者的术前血红蛋白、术后引流量及术后第1、4及7天血红蛋白和总失血量,并比较其术后输血率、输血量及发生深静脉血栓的概率。结果实验组术后24 h引流量、隐性失血量及总失血量均低于对照组,差异有统计学意义(P0.05);两组患者术前血红蛋白、红细胞比容(HCT)比较,差异无统计学意义(P0.05),术后第1、4及7天血红蛋白、HCT比较,实验组均高于对照组,差异有统计学意义(P0.05);实验组输血率和接受输血量均低于对照组,差异有统计学意义(P0.05);两组患者术后深静脉血栓发生率分别为16.7%及10%,差异无统计学意义(P0.05)。结论高负压引流基础上联合氨甲环酸局部注射可以降低单侧初次全膝关节置换术后出血及输血需求,并不增加深静脉血栓的发生率。
[Abstract]:Objective to investigate the effect of local injection of carbamicylic acid on blood loss after primary unilateral total knee arthroplasty. Methods A randomized controlled study was conducted in 60 patients with osteoarthritis in the department of joint surgery of Hunan Provincial people's Hospital from December 2013 to August 2016. The articular capsule was randomly divided into experimental group (n = 30) and control group (n = 30). Experimental group: 10 ml (1.0 g) carbamoic acid was injected into the articular capsule before the closure of the articular cavity and the high negative pressure drainage bottle was placed in the control group: before the closure of the articular cavity, 10 ml normal saline was injected locally around the capsule wall of the joint. Also place a high negative pressure drain bottle. The preoperative hemoglobin, postoperative drainage volume, hemoglobin and total blood loss were recorded, and the blood transfusion rate, blood transfusion volume and the probability of deep venous thrombosis were compared between the two groups. Results 24 hours after operation, the volume of recessive blood loss and total blood loss in the experimental group were significantly lower than those in the control group (P0.05), the hemoglobin and erythrocyte specific volume (HCT) were compared between the two groups before operation. There was no significant difference (P0.05). The HCT in the experimental group was higher than that in the control group on the 4th and 7th day after operation (P0.05); the blood transfusion rate and the volume of blood transfusion in the experimental group were lower than those in the control group. The difference was statistically significant (P0.05); the incidence of deep venous thrombosis in the two groups was 16.7% and 10% respectively, the difference was not statistically significant (P0.05). Conclusion Local injection of carbamate on the basis of high negative pressure drainage can reduce bleeding and blood transfusion demand after unilateral primary total knee arthroplasty without increasing the incidence of deep venous thrombosis.
【作者单位】： 湖南省人民医院关节外科;南华大学;
【分类号】：R687.4
[Abstract]:Objective to investigate the effect of local injection of carbamicylic acid on blood loss after primary unilateral total knee arthroplasty. Methods A randomized controlled study was conducted in 60 patients with osteoarthritis in the department of joint surgery of Hunan Provincial people's Hospital from December 2013 to August 2016. The articular capsule was randomly divided into experimental group (n = 30) and control group (n = 30). Experimental group: 10 ml (1.0 g) carbamoic acid was injected into the articular capsule before the closure of the articular cavity and the high negative pressure drainage bottle was placed in the control group: before the closure of the articular cavity, 10 ml normal saline was injected locally around the capsule wall of the joint. Also place a high negative pressure drain bottle. The preoperative hemoglobin, postoperative drainage volume, hemoglobin and total blood loss were recorded, and the blood transfusion rate, blood transfusion volume and the probability of deep venous thrombosis were compared between the two groups. Results 24 hours after operation, the volume of recessive blood loss and total blood loss in the experimental group were significantly lower than those in the control group (P0.05), the hemoglobin and erythrocyte specific volume (HCT) were compared between the two groups before operation. There was no significant difference (P0.05). The HCT in the experimental group was higher than that in the control group on the 4th and 7th day after operation (P0.05); the blood transfusion rate and the volume of blood transfusion in the experimental group were lower than those in the control group. The difference was statistically significant (P0.05); the incidence of deep venous thrombosis in the two groups was 16.7% and 10% respectively, the difference was not statistically significant (P0.05). Conclusion Local injection of carbamate on the basis of high negative pressure drainage can reduce bleeding and blood transfusion demand after unilateral primary total knee arthroplasty without increasing the incidence of deep venous thrombosis.
【作者单位】： 湖南省人民医院关节外科;南华大学;
【分类号】：R687.4
【相似文献】
相关期刊论文 前10条
1 陈艰;氨甲环酸在体外循环心脏手术中的应用[J];江苏医药;1997年03期
2 赵e鹒，
本文编号：2219013
本文链接：https://www.wllwen.com/yixuelunwen/waikelunwen/2219013.html
最近更新
教材专著
