丁丙诺啡透皮贴剂对老年股骨转子间骨折术后的镇痛效果与安全性

发布时间：2018-10-09 07:27

【摘要】：目的观察老年股骨转子间骨折术后使用丁丙诺啡透皮贴剂止痛临床效果。方法将67例老年股骨转子间骨折术后患者分为试验组34例和对照组33例。试验组术后予以丁丙诺啡透皮贴剂,对照组术后予以同等包装不含丁丙诺啡药用成分的空白贴剂。术后第1,2,3,4,5,6,7天,记录2组患者收缩压、舒张压、心率、视觉模拟评分(VAS),同时统计药物不良反应。结果治疗后第2,3,4,5天,试验组的VAS分别为(6.69±1.83),(4.22±1.56),(3.73±2.20),(3.13±1.58);对照组的VAS分别为(8.15±1.36),(7.75±2.26),(7.14±1.67),(6.82±2.24),组间比较差异有统计学意义(P0.05)。试验组的药物不良反应主要有恶心呕吐、皮疹,对照组的药物不良反应主要有恶心呕吐,2组药物不良反应发生率分别为23.53%和6.06%,差异有统计学意义(P0.05)。结论研究表明丁丙诺啡透皮贴剂对老年股骨转子间骨折术后有更好的镇痛效果,但术后2日内注意药物不良反应的发生。
[Abstract]:Objective to observe the effect of buprenorphine transdermal patch on pain relief after intertrochanteric fracture in the elderly. Methods 67 elderly patients with intertrochanteric fracture were divided into trial group (n = 34) and control group (n = 33). The experimental group was treated with buprenorphine transdermal patch and the control group with the same package of blank patch without buprenorphine. Systolic blood pressure, diastolic blood pressure, heart rate and visual analogue score (VAS),) were recorded on 7 days after operation. Results the VAS of the experimental group was (6.69 卤1.83), (4.22 卤1.56), (3.73 卤2.20), (3.13 卤1.58) and the VAS of the control group was (8.15 卤1.36), (7.75 卤2.26), (7.14 卤1.67), (6.82 卤2.24) 5 days after treatment. There was significant difference between the two groups (P0.05). The main adverse drug reactions in the trial group were nausea and vomiting, rash, the main adverse drug reactions in the control group were nausea and vomiting, the incidence of adverse drug reactions were 23.53% and 6.06% respectively, the difference was statistically significant (P0.05). Conclusion the results showed that buprenorphine transdermal patch had better analgesic effect in elderly patients with intertrochanteric fracture, but attention should be paid to the occurrence of adverse drug reactions within 2 days after operation.
【作者单位】：西安医学院第一附属医院骨科;西安医学院第一附属医院麻醉科;
【基金】：陕西省社会发展科技攻关基金资助项目(2016SF-111)
【分类号】：R687.3

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