CEA和PTEN在双侧原发性乳腺癌中的表达和分析

发布时间：2018-10-16 21:21

【摘要】：目的:检测原发性双侧乳腺癌左右两侧病理石蜡切片中CEA和PTEN表达和表达强度差异,揭示其发生是单克隆还是独立克隆性。对比分析双侧病灶之间以及与单侧同病理类型之间蛋白表达差异。方法:9例原发性双侧乳腺癌左右组织标本共18个,对应单侧乳腺癌患者乳腺组织标本10个。免疫组织化学法检测CEA和PTEN表达情况。结果:双侧乳腺癌第一癌与第二癌和单侧乳腺癌中CEA表达率分别为66.6%(6/9)、55.5%(5/9)、60%(6/10)、PTEN在第一癌、第二癌、单侧乳腺癌中表达率分别为33.3%(3/9)、44.4%(4/9)、50%(5/10)、表达差异均无统计学意义(P0.05),双侧乳腺癌CEA中同为阳性为5例,同为阴性为3例,PTEN中同为阳性为3例,同为阴性为5例。结论:双侧乳腺癌首发癌和单侧乳腺癌中CEA、PTEN蛋白的表达均无统计学差异。双侧乳腺癌第一癌与第二癌中CEA、PTEN蛋白的表达差异无统计学差异,提示双侧乳腺癌第一癌和第二癌为单克隆性。
[Abstract]:Objective: to detect the expression and expression intensity of CEA and PTEN in the paraffin sections of bilateral primary breast cancer and to reveal whether they are monoclonal or independent. The differences of protein expression between bilateral lesions and unilateral histopathological types were compared. Methods: there were 18 primary bilateral breast cancer tissues in 9 cases and 10 breast tissue specimens corresponding to unilateral breast cancer. The expression of CEA and PTEN was detected by immunohistochemistry. Results: the expression rates of CEA were 66.6% (6 / 9), 55.5% (5 / 9), 60% (6 / 10), PTEN) in the first and second breast cancers, respectively. The expression rates in unilateral breast cancer were 33.3% (3 / 9), 44.4% (4 / 9) and 50% (5 / 10), respectively. There was no significant difference (P0.05). In bilateral breast cancer, 5 cases were positive in CEA, 3 cases were negative, 3 cases were positive in PTEN and 5 cases were negative. Conclusion: there is no significant difference in the expression of CEA,PTEN protein between primary and unilateral breast cancer. There was no significant difference in the expression of CEA,PTEN protein between the first and second carcinomas of bilateral breast cancer, suggesting that the first and second carcinomas of bilateral breast cancer were monoclonal.
【学位授予单位】：遵义医学院
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R737.9

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