基于骨-软骨交互作用探析骨关节炎发病机制及治疗策略

发布时间：2018-10-24 07:08

【摘要】：背景:骨关节炎作为退行性关节疾病,软骨损伤和组织缺失不能完全解释其发病机制,骨重建的失衡以及关节内组织相互作用可能在疾病过程中有重要意义。目的:对骨-软骨交互作用在骨关节炎的发生发展过程中产生的作用及新的治疗策略进行综述。方法:由第一作者检索2007至2017年Pub Med及中国知网等数据库收录的关于骨关节炎的发生发展与骨-软骨交互作用关系的实验研究及研究进展的文献。中文检索词分别为"骨、软骨、交互作用、骨关节炎、发病机制、细胞因子、信号通路",英文检索词分别为"cartilage;interaction;osteoarthritis;pathogenesis;cytokines;signaling pathway",文章从细胞因子、信号通路、新型治疗策略3个方面,对骨-软骨交互作用与骨关节炎发生发展的关系进行综述。结果与结论:共检索到169篇文章,按纳入和排除标准对文献进行筛选,共纳入54篇文章。软骨同软骨下骨的解剖结构联系密切,骨与软骨构成了一个功能协同的整体单元。在骨关节炎发生发展过程中,骨重建异常以及新生血管数量的增加、微裂缝的形成,促进了分子信号在骨-软骨间的转位和交互作用。骨-软骨的交互作用是骨关节炎发生发展的病理中心。
[Abstract]:Background: osteoarthritis, as a degenerative joint disease, cartilage injury and tissue loss can not fully explain the pathogenesis of osteoarthritis. The imbalance of bone reconstruction and intra-articular tissue interaction may play an important role in the process of the disease. Objective: to review the role of bone-cartilage interaction in the occurrence and development of osteoarthritis. Methods: the first author searched the literature on the relationship between the occurrence and development of osteoarthritis and the interaction between osteochondral and osteoarthritis, which were collected from 2007 to 2017 by Pub Med and China Zhiwang. The Chinese key words were "bone, cartilage, interaction, osteoarthritis, pathogenesis, cytokine, signal pathway", and the English key words were "cartilage;interaction;osteoarthritis;pathogenesis;cytokines;signaling pathway". The relationship between osteochondral interaction and the occurrence and development of osteoarthritis was reviewed. Results & conclusion: a total of 169 articles were retrieved, and 54 articles were selected according to inclusion and exclusion criteria. Cartilage is closely related to the anatomical structure of subchondral bone. In the process of osteoarthritis, abnormal bone reconstruction, increased number of neovascularization and formation of microcracks promote the translocation and interaction of molecular signals between bone and cartilage. Bone-cartilage interaction is the pathological center of osteoarthritis.
【作者单位】：南京中医药大学骨伤研究所;无锡市中医医院骨伤科;
【基金】：江苏省科技项目合同(BK20151007) 无锡市医院管理中心科研项目(YGZXM14046) 无锡市卫生和计划生育委员会科研项目(Q201503) 江苏省普通高校研究生科研创新计划项目(KYZZ16_0409)~~
【分类号】：R684.3

【相似文献】