基于骨-软骨交互作用探析骨关节炎发病机制及治疗策略
[Abstract]:Background: osteoarthritis, as a degenerative joint disease, cartilage injury and tissue loss can not fully explain the pathogenesis of osteoarthritis. The imbalance of bone reconstruction and intra-articular tissue interaction may play an important role in the process of the disease. Objective: to review the role of bone-cartilage interaction in the occurrence and development of osteoarthritis. Methods: the first author searched the literature on the relationship between the occurrence and development of osteoarthritis and the interaction between osteochondral and osteoarthritis, which were collected from 2007 to 2017 by Pub Med and China Zhiwang. The Chinese key words were "bone, cartilage, interaction, osteoarthritis, pathogenesis, cytokine, signal pathway", and the English key words were "cartilage;interaction;osteoarthritis;pathogenesis;cytokines;signaling pathway". The relationship between osteochondral interaction and the occurrence and development of osteoarthritis was reviewed. Results & conclusion: a total of 169 articles were retrieved, and 54 articles were selected according to inclusion and exclusion criteria. Cartilage is closely related to the anatomical structure of subchondral bone. In the process of osteoarthritis, abnormal bone reconstruction, increased number of neovascularization and formation of microcracks promote the translocation and interaction of molecular signals between bone and cartilage. Bone-cartilage interaction is the pathological center of osteoarthritis.
【作者单位】: 南京中医药大学骨伤研究所;无锡市中医医院骨伤科;
【基金】:江苏省科技项目合同(BK20151007) 无锡市医院管理中心科研项目(YGZXM14046) 无锡市卫生和计划生育委员会科研项目(Q201503) 江苏省普通高校研究生科研创新计划项目(KYZZ16_0409)~~
【分类号】:R684.3
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