库欣病术后不同阶段不同切点值的皮质醇水平与长期疗效的相关性分析

发布时间：2018-11-05 15:56

【摘要】：目的探讨库欣病术后不同阶段不同切点值的皮质醇水平与长期疗效的相关性。方法回顾性分析1985年5月至2008年6月在北京协和医院神经外科行经蝶窦入路手术的102例库欣病患者的临床资料,比较术后次日,3、6个月清晨血清皮质醇小于2μg/dl(2μg/dl组)和2~5μg/dl(5μg/dl组)患者的长期随访疗效。结果本组平均随访时间为(10.7±1.7)年(5~29.1年)。74例(72.5%)治愈,28例(27.5%)复发。术后次日,2μg/dl组63例患者中,48例(76.2%)达到长期治愈;5μg/dl组39例患者中,26例(66.7%)达到长期治愈;两组间差异无统计学意义(χ2=1.097,P=0.295)。术后3个月,2μg/dl组57例患者中,48例(84.2%)达到长期治愈;5μg/dl组40例患者中,26例(65.0%)达到长期治愈;两组间差异有统计学意义(χ2=4.795,P=0.029)。术后6个月,2μg/dl组53例患者中,47例(88.7%)达到长期治愈;5μg/dl组39例患者中,27例(69.2%)达到长期治愈;两组间差异有统计学意义(χ2=5.400,P=0.020)。结论库欣病术后3和6个月清晨血清皮质醇小于2μg/dl比2~5μg/dl更能预测长期治愈。
[Abstract]:Objective to investigate the correlation between cortisol level and long-term curative effect in different stages of Cushing's disease. Methods the clinical data of 102 patients with Cushing's disease underwent transsphenoidal approach from May 1985 to June 2008 in Peking Union Hospital were analyzed retrospectively. Long term follow-up of patients with serum cortisol less than 2 渭 g/dl (2 渭 g/dl group) and 2 5 渭 g/dl (5 渭 g/dl group) in the morning of 3 and 6 months. Results the mean follow-up time was (10.7 卤1.7) years (5 ~ 29.1 years), 74 cases (72.5%) were cured and 28 cases (27.5%) recurred. The second day after operation, 48 (76.2%) of 63 patients in 2 渭 g/dl group and 26 (66.7%) of 39 patients in 5 渭 g/dl group were cured for a long time (蠂 ~ 2, 1.097, P ~ (0.295). Three months after operation, 48 (84.2%) of 57 patients in 2 渭 g/dl group and 26 (65.0%) of 40 patients in 5 渭 g/dl group were cured for a long time (蠂 2, 4.795, P < 0. 029). At 6 months after operation, 47 (88.7%) of 53 patients in 2 渭 g/dl group and 27 (69.2%) of 39 patients in 5 渭 g/dl group were cured for a long time (蠂 ~ (2 +) 5.400 P ~ (0.020). Conclusion Serum cortisol less than 2 渭 g/dl is better than 2 渭 g/dl in predicting long-term cure of Cushing's disease 3 and 6 months after operation.
【作者单位】：中国医学科学院北京协和医学院北京协和医院神经外科卫生部内分泌重点实验室;
【基金】：首都临床特色应用研究与成果推广(Z151100004015099)~~
【分类号】：R651

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