盐酸纳布啡注射液用于剖宫产术后镇痛的临床研究及其对产后抑郁的预防作用
发布时间：2018-11-10 18:23
【摘要】：目的观察盐酸纳布啡注射液用于剖宫产术后镇痛的临床疗效和安全性,及其对产后抑郁的预防作用。方法将400例剖宫产手术的足月妊娠产妇随机分为A、B、C、D组,每组100例。A组术后予以舒芬太尼100μg,静脉自控镇痛;B组术后予以盐酸纳布啡1.5 mg·kg-1,静脉自控镇痛;C组术后予以盐酸纳布啡2.0 mg·kg-1,静脉自控镇痛;D组术后予以盐酸纳布啡2.5 mg·kg~(-1),静脉自控镇痛。比较4组产妇术后6,12,24 h的视觉模拟评分法(VAS)和Ramsay镇静评分法(RSS)评分、抑郁状况,以及药物不良反应的发生情况。结果术后6,12,24 h,A组的VAS评分分别为(3.21±0.44),(3.15±0.49),(2.06±0.49)分,RSS评分分别为(2.08±0.37),(2.05±0.35),(1.85±0.23)分;B组的VAS评分分别为(2.17±0.35),(2.00±0.38),(1.45±0.38)分,RSS评分分别为(2.01±0.19),(1.91±0.21),(1.72±0.18)分;C组的VAS评分分别为(2.08±0.22),(1.53±0.26),(0.75±0.13)分,RSS评分分别为(1.71±0.15),(1.75±0.12),(1.46±0.15)分;D组的VAS评分分别为(2.10±0.21),(1.52±0.21),(0.72±0.11)分,RSS评分分别为(1.64±0.22),(1.62±0.15),(1.43±0.21)分,在不同时间点C、D组的VAS评分和RSS评分与A、B组比较,差异均有统计学意义(均P0.05)。产后3 d,A、B、C、D组的抑郁率分别为35.00%(35/100例),27.00%(27/100例),12.00%(12/100例),26.00%(26/100例),C组与A、B、D组比较,差异均有统计学意义(均P0.05)。A组的药物不良反应主要有心率下降、恶性呕吐、腹泻、皮疹,B、C组的药物不良反应主要有心跳过快、恶心呕吐、尿潴留,D组的药物不良反应主要有心跳过快、恶心呕吐、腹泻、皮疹。A、B、C、D组药物不良反应发生率为14.00%,10.00%,11.00%,21.00%,D组与A、B、C组间相互比较差异均有统计学意义(均P0.05)。结论盐酸纳布啡2.0 mg·kg-1对剖宫产术后的镇痛、镇静效果显著,且产后抑郁率和药物不良反应发生率较低。
[Abstract]:Objective to observe the clinical efficacy and safety of naporphine hydrochloride injection in postoperative analgesia of cesarean section and its preventive effect on postpartum depression. Methods 400 pregnant women undergoing cesarean section were randomly divided into group A (n = 100) and group A (n = 100). Group B received intravenous analgesia with 1. 5 mg kg-1, group C received 2. 0 mg kg-1, intravenously controlled analgesia after operation. Group D was treated with 2. 5 mg kg~ (- 1) naporphine hydrochloride and patient controlled intravenous analgesia. The visual analogue score (VAS) and Ramsay sedation score (RSS), depression status and adverse drug reaction were compared in 4 groups. Results the VAS score of group A was (3.21 卤0.44), (卤0.49), (卤2.06 卤0.49) and the score of RSS was (2.08 卤0.37), (2.05 卤0.35), (1.85 卤0.23). The VAS score of group B was (2.17 卤0.35), () 2.00 卤0.38), (1.45 卤0.38) and the score of RSS was (2.01 卤0.19), (1.91 卤0.21), (1.72 卤0.18); The VAS score of group C was (2.08 卤0.22), () 1.53 卤0.26), (0.75 卤0.13), the RSS score was (1.71 卤0.15), () 1.75 卤0.12), (1.46 卤0.15); The VAS score of group D was (2.10 卤0.21), (卤0.21), (0.72 卤0.11), the RSS score of group D was (1.64 卤0.22), (1.62 卤0.15), (1.43 卤0.21), and the score of RSS was (1.64 卤0.22), (1.62 卤0.15), (1.43 卤0.21) at different time points. The VAS score and RSS score of group D were significantly different from those of group B (P0.05). The depression rates in group D were 35.00% (35 / 100), 27.00% (27 / 100), 12.00% (12 / 100), 26.00% (26 / 100), respectively. The difference was statistically significant (P0.05) in). A group, the main adverse drug reactions were heart rate decline, vomiting, diarrhea, rash, heart rate, nausea and vomiting, urine retention. The main adverse drug reactions in group D were heart rate, nausea and vomiting, diarrhea and rash. The incidence of adverse drug reactions in group D was 14.00 and 10.00, 11.00 and 21.00 respectively. The difference between group C and group C was statistically significant (P0.05). Conclusion the analgesic effect and sedation effect of nalbacine hydrochloride 2.0 mg kg-1 were significant after cesarean section, and the incidence of postpartum depression and adverse drug reactions were lower.
【作者单位】： 青岛大学附属青岛妇女儿童医院麻醉科;
【基金】：青岛市医药科研指导计划基金资助(2015-WJZD085)
【分类号】：R614
本文编号：2323245
[Abstract]:Objective to observe the clinical efficacy and safety of naporphine hydrochloride injection in postoperative analgesia of cesarean section and its preventive effect on postpartum depression. Methods 400 pregnant women undergoing cesarean section were randomly divided into group A (n = 100) and group A (n = 100). Group B received intravenous analgesia with 1. 5 mg kg-1, group C received 2. 0 mg kg-1, intravenously controlled analgesia after operation. Group D was treated with 2. 5 mg kg~ (- 1) naporphine hydrochloride and patient controlled intravenous analgesia. The visual analogue score (VAS) and Ramsay sedation score (RSS), depression status and adverse drug reaction were compared in 4 groups. Results the VAS score of group A was (3.21 卤0.44), (卤0.49), (卤2.06 卤0.49) and the score of RSS was (2.08 卤0.37), (2.05 卤0.35), (1.85 卤0.23). The VAS score of group B was (2.17 卤0.35), () 2.00 卤0.38), (1.45 卤0.38) and the score of RSS was (2.01 卤0.19), (1.91 卤0.21), (1.72 卤0.18); The VAS score of group C was (2.08 卤0.22), () 1.53 卤0.26), (0.75 卤0.13), the RSS score was (1.71 卤0.15), () 1.75 卤0.12), (1.46 卤0.15); The VAS score of group D was (2.10 卤0.21), (卤0.21), (0.72 卤0.11), the RSS score of group D was (1.64 卤0.22), (1.62 卤0.15), (1.43 卤0.21), and the score of RSS was (1.64 卤0.22), (1.62 卤0.15), (1.43 卤0.21) at different time points. The VAS score and RSS score of group D were significantly different from those of group B (P0.05). The depression rates in group D were 35.00% (35 / 100), 27.00% (27 / 100), 12.00% (12 / 100), 26.00% (26 / 100), respectively. The difference was statistically significant (P0.05) in). A group, the main adverse drug reactions were heart rate decline, vomiting, diarrhea, rash, heart rate, nausea and vomiting, urine retention. The main adverse drug reactions in group D were heart rate, nausea and vomiting, diarrhea and rash. The incidence of adverse drug reactions in group D was 14.00 and 10.00, 11.00 and 21.00 respectively. The difference between group C and group C was statistically significant (P0.05). Conclusion the analgesic effect and sedation effect of nalbacine hydrochloride 2.0 mg kg-1 were significant after cesarean section, and the incidence of postpartum depression and adverse drug reactions were lower.
【作者单位】： 青岛大学附属青岛妇女儿童医院麻醉科;
【基金】：青岛市医药科研指导计划基金资助(2015-WJZD085)
【分类号】：R614
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