冻结肩患者肩关节致纤维化细胞因子和炎症细胞因子的表达

发布时间：2018-11-11 15:19

【摘要】：目的探讨致纤维化细胞因子和炎症细胞因子在冻结肩发生中的可能作用。方法 2014年9月至2016年4月,20例冻结肩患者接受肩关节镜手术,其中原发性冻结肩10例(A组),继发性冻结肩10例(B组)。以同期接受肩关节镜手术的10例非冻结肩患者作为对照(C组)。q PCR检测肩关节滑膜组织中基质金属蛋白酶1(MMP1)、MMP3、肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、IL-6、IL-8、粒细胞巨噬细胞集落刺激因子(GM-CSF)和巨噬细胞集落刺激因子(M-CSF)m RNA表达水平。结果 A组和B组MMP1和MMP3 m RNA表达高于C组(P0.05),TNF-α、IL-1、IL-6、IL-8、GM-CSF和M-CSF m RNA显著高于C组(P0.001),A组和B组间各因子m RNA表达无显著性差异(P0.05)。结论冻结肩的发生可能与患者关节滑膜组织中致纤维化细胞因子和炎症细胞因子的高表达有关。
[Abstract]:Objective to investigate the possible role of fibrogenic cytokines and inflammatory cytokines in the development of frozen shoulder. Methods from September 2014 to April 2016, 20 patients with frozen shoulder underwent arthroscopic surgery, including 10 patients with primary frozen shoulder (group A) and 10 patients with secondary frozen shoulder (group B). Ten patients with unfrozen shoulder underwent arthroscopic shoulder surgery were used as control group (group C,). Q PCR was used to detect matrix metalloproteinase-1 (MMP1), MMP3, tumor necrosis factor- 伪 (TNF- 伪) in synovial tissue of shoulder joint). Interleukin-1 (IL-1), IL-6,IL-8, granulocyte macrophage colony stimulating factor (GM-CSF) and macrophage colony stimulating factor (M-CSF) m RNA) were expressed. Results the expression of MMP1 and MMP3 m RNA in group A and group B was higher than that in group C (P0.05). The expression of TNF- 伪, IL-1,IL-6,IL-8,GM-CSF and M-CSF m RNA was significantly higher in group A than in group C (P0.001). There was no significant difference in the expression of m RNA between group A and group B (P 0.05). Conclusion the occurrence of frozen shoulder may be related to the high expression of fibrogenic cytokines and inflammatory cytokines in synovial tissue.
【作者单位】：首都医科大学康复医学院;中国康复研究中心北京博爱医院骨科;
【基金】：北京丰台区卫生系统科学研究项目(No.2014-丰台) 中央级公益性科研院所基本科研业务费专项资金项目(No.2015CZ-13)
【分类号】：R684

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