自体单采富血小板血浆凝胶临床制作与应用

发布时间：2018-11-19 19:32

【摘要】：目的介绍利用全自动血液成分分离机制备自体富血小板血浆凝胶技术及其临床应用,总结其在各类创面修复中的应用方法及效果,并与传统制作方法进行比较,为临床修复各类创面提供新方案及治疗建议。方法 2013年1月至2016年3月,笔者科室使用全自动血液成分分离机制备自体富血小板血浆凝胶技术,治疗各类创面92例。创面处理前,先使用全自动血液采集装置采集血小板,后二次离心浓缩,制成富血小板血浆;术中创面行彻底清创后,将富血小板血浆注入窦道或涂于创面,通过激活剂激活形成凝胶,术后经负压吸引治疗,定期更换辅料,部分创面可换药愈合,部分可通过自体皮移植修复。结果使用全自动血液成分分离机制备自体富血小板血浆凝胶技术治疗各类急慢性创面92例,创面肉芽增生满意,窦道封闭良好,抗感染能力强,特别对于骨质、肌腱外露创面,肉芽覆盖速度快,对于窦道封闭效果好,术后复查无死腔。结论全自动血液成分分离机制备自体富血小板血浆凝胶技术治疗各类急慢性创面,较以往换药、负压、手术清创、皮瓣(肌皮瓣)等修复方式有较大优势,同时与自体全血离心技术采集富血小板血浆凝胶比较,优势明显;该治疗技术简单易行,损伤小,治疗时间短,不易复发,安全可靠。
[Abstract]:Objective to introduce the technique of preparing autologous platelet-rich plasma gel with automatic blood component separator and its clinical application, and to summarize the application and effect of autoplatelet-rich plasma gel in all kinds of wound repair, and to compare it with the traditional method. To provide a new plan and treatment suggestions for clinical repair of various kinds of wounds. Methods from January 2013 to March 2016, the author used automatic blood component separator to prepare autologous platelet-rich plasma gel technique to treat 92 cases of various wounds. Before the wound treatment, the platelets were collected with automatic blood collection device, and then centrifuged and concentrated twice to make platelet-rich plasma. After thorough debridement, platelet-rich plasma was injected into the sinus tract or coated on the wound, then activated by activator to form gel. After operation, the wound was treated by negative pressure, and the excipients were changed regularly. Some can be repaired by skin autograft. Results 92 cases of acute and chronic wounds were treated with autogenous platelet-rich plasma gel prepared by automatic blood component separator. The granulation of wound was satisfactory, the sinus was closed well, and the ability of anti-infection was strong, especially for the exposed wounds of bone and tendon. The granulation cover speed is fast, for the sinus closure effect is good, the postoperative reexamination has no dead cavity. Conclusion Autologous platelet-rich plasma gel technique for the treatment of various acute and chronic wounds by automatic blood component separator has more advantages than the previous methods of dressing change, negative pressure, surgical debridement, flap (myocutaneous flap) and so on. At the same time, compared with autologous whole blood centrifugation to collect platelet-rich plasma gel, the advantage was obvious. The treatment technique is simple and feasible, the injury is small, the treatment time is short, the recurrence is not easy, and the treatment is safe and reliable.
【作者单位】：解放军总医院第一附属医院烧伤整形科三病区创面修复中心;
【基金】：国家自然科学基金青年科学基金项目(81601730) 全军后勤科研计划重点项目(BWS14J049) 首都卫生发展科研专项课题(首发2014-2-5024) 首都临床特色应用研究专项课题(Z141107002514167)
【分类号】：R641

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