骨关节炎临床表现特点及沉默信息调节因子1在其发病中的作用
发布时间：2018-11-21 16:00
【摘要】：背景:研究发现一些功能性基因的功能变化是引发骨关节炎的调控环节,而年龄可能是其中的关键因素之一。目的:对近年来骨关节炎中的临床现表现特点及沉默信息调节因子1在骨关节炎发生发展中的研究进展做一概述。方法:计算机检索相关期刊论文、Pub Med、Springer Link、Elsevier Science Direct数据库,检索时间1987年1月至2016年1月,检索词分别为"骨关节炎;沉默信息调节因子1;软骨"和"Osteoarthritis,Cartilage,Silent information regulation 1"。对纳入符合标准的83条文献进行分析。结果与结论:研究表明,在多种信号通路中去乙酰化修饰调控大量细胞因子的表达和生物学功能,继而影响骨关节炎的发生和发展。沉默信息调节因子1具有调节机体代谢,抑制细胞凋亡,修复DNA损伤,延缓衰老,抵抗应激反应等重要作用,同时在表观遗传学修饰、基因沉默和信号转导调节中发挥着重要的生物学功能,因此沉默信息调节因子1与各种年龄相关的疾病有关,如骨关节炎、骨质疏松症、糖尿病和阿尔茨海默症等。沉默信息调节因子1有望成为开发治疗骨关节炎药物的重要靶点,甚至可能在骨关节炎不成熟的阶段,逆转机械应力导致的软骨功能损伤。
[Abstract]:Background: it has been found that the functional changes of some functional genes are involved in the regulation of osteoarthritis, and age may be one of the key factors. Objective: to summarize the clinical features of osteoarthritis in recent years and the progress of silent information regulating factor 1 in the development of osteoarthritis. Methods: the full text database and Pub Med,Springer Link,Elsevier Science Direct database of Chinese periodicals were searched by computer from January 1987 to January 2016. The key words were "osteoarthritis", "silent information regulation factor 1" and "silent information regulation factor 1" respectively. Cartilage and Osteoarthritis,Cartilage,Silent information regulation 1. The 83 articles that meet the standard were analyzed. Results & conclusion: deacetylation can regulate the expression and biological function of cytokines in many signal pathways, and then affect the occurrence and development of osteoarthritis. Silencing information regulatory factor 1 plays an important role in regulating metabolism, inhibiting cell apoptosis, repairing DNA damage, delaying senescence, resisting stress response and so on. Gene silencing and signal transduction regulation play important biological functions, so silencing information regulatory factor 1 is associated with various age-related diseases, such as osteoarthritis, osteoporosis, diabetes and Alzheimer's disease. Silencing information regulatory factor 1 is expected to be an important target for the development of drugs for the treatment of osteoarthritis. It may even reverse the damage of cartilage function caused by mechanical stress in the immature stage of osteoarthritis.
【作者单位】： 北京大学深圳医院骨关节科;北京大学人民医院创伤骨科;
【基金】：国家自然科学基金面上项目(81272032) 深圳市科工贸与信息委员会重点项目(201101001)~~
【分类号】：R684.3
，
本文编号：2347444
[Abstract]:Background: it has been found that the functional changes of some functional genes are involved in the regulation of osteoarthritis, and age may be one of the key factors. Objective: to summarize the clinical features of osteoarthritis in recent years and the progress of silent information regulating factor 1 in the development of osteoarthritis. Methods: the full text database and Pub Med,Springer Link,Elsevier Science Direct database of Chinese periodicals were searched by computer from January 1987 to January 2016. The key words were "osteoarthritis", "silent information regulation factor 1" and "silent information regulation factor 1" respectively. Cartilage and Osteoarthritis,Cartilage,Silent information regulation 1. The 83 articles that meet the standard were analyzed. Results & conclusion: deacetylation can regulate the expression and biological function of cytokines in many signal pathways, and then affect the occurrence and development of osteoarthritis. Silencing information regulatory factor 1 plays an important role in regulating metabolism, inhibiting cell apoptosis, repairing DNA damage, delaying senescence, resisting stress response and so on. Gene silencing and signal transduction regulation play important biological functions, so silencing information regulatory factor 1 is associated with various age-related diseases, such as osteoarthritis, osteoporosis, diabetes and Alzheimer's disease. Silencing information regulatory factor 1 is expected to be an important target for the development of drugs for the treatment of osteoarthritis. It may even reverse the damage of cartilage function caused by mechanical stress in the immature stage of osteoarthritis.
【作者单位】： 北京大学深圳医院骨关节科;北京大学人民医院创伤骨科;
【基金】：国家自然科学基金面上项目(81272032) 深圳市科工贸与信息委员会重点项目(201101001)~~
【分类号】：R684.3
，
本文编号：2347444
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