促红细胞生成素在开颅动脉瘤夹闭术后脑缺血中的应用效果

发布时间：2018-11-27 20:04

【摘要】：目的观察促红细胞生成素在开颅动脉瘤夹闭术后脑缺血治疗中的应用效果。方法选取宜宾市第三人民医院2013年6月到2014年6月间的100例开颅动脉瘤夹闭术脑缺血患者为研究对象,将其按照随机数字表法分为研究组与对照组,对照组患者给予改善脑循环、血管痉挛、保护脑组织的药物进行治疗,研究组在常规治疗基础应用促红细胞生成素,观察两组患者治疗前后NIHSS评分,治疗后不同时间点脑缺血面积缩小率、超氧化物歧化酶(SOD)、丙二醛(MDA)变化。结果治疗后研究组与对照组的NIHSS评分较治疗前有明显降低,且研究组降低程度优于对照组,比较差异有统计学意义(P0.05)。手术后第3周、第4周和第5周的研究组与对照组脑缺血面积缩小率较治疗前有明显的提高,且研究组提高程度优于对照组,比较差异有统计学意义(P0.05)。研究组MDA水平明显的低于对照组,而SOD水平高于对照组,比较差异有统计学意义(P0.05)。结论临床中应用促红细胞生成素可以通过促进缺血脑组织的微循环重建,从而改善脑缺血的临床症状并对神经细胞起到保护作用。
[Abstract]:Objective to observe the effect of erythropoietin on cerebral ischemia after intracranial aneurysm closure. Methods from June 2013 to June 2014, 100 patients with cerebral ischemia underwent clipping operation in Yibin third people's Hospital were selected and divided into study group and control group according to random digital table. The patients in the control group were treated with drugs to improve cerebral circulation, vasospasm and brain tissue protection. The patients in the study group were treated with Erythropoietin on the basis of routine treatment. The NIHSS scores of the two groups were observed before and after treatment. The reduction rate of cerebral ischemia area and the changes of (SOD), malondialdehyde (MDA) (MDA) were observed at different time points after treatment. Results the NIHSS score of the study group and the control group was significantly lower than that of the control group after treatment, and the decrease degree of the study group was better than that of the control group, the difference was statistically significant (P0.05). The reduction rate of cerebral ischemia area in the study group and the control group was significantly higher than that in the control group at the 3rd week, 4th week and 5th week after operation, and the improvement degree of the study group was better than that of the control group, the difference was statistically significant (P0.05). The level of MDA in the study group was significantly lower than that in the control group, while the level of SOD was higher than that in the control group (P0.05). Conclusion Erythropoietin can improve the clinical symptoms of cerebral ischemia and protect nerve cells by promoting the reconstruction of microcirculation in ischemic brain tissue.
【作者单位】：四川省宜宾市第三人民医院神经外科;四川省宜宾市第二人民医院神经外科;
【分类号】：R651.12

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