骨转移癌217例临床分析

发布时间：2018-12-07 16:47

【摘要】：目的探讨并分析骨转移癌的临床特点,提高骨转移癌的诊治水平。方法对217例骨转移癌患者的临床资料进行回顾性分析,总结原发肿瘤、年龄分布、首发症状、发病时间、骨转移部位等临床特点,运用视觉模拟评分(VAS)评价唑来膦酸治疗前后骨转移灶疼痛差异。结果骨转移癌患者以男性多见,男女比例为1.28∶1。原发肿瘤以肺癌(51.61%)、乳腺癌(15.67%)相对多见。50~70岁是骨转移发病的高峰。骨转移癌患者大多以不同程度的疼痛为最初不适,少数则以功能障碍、病理性骨折、局部肿块为首发症状,个别为无意间发现。发病时间在3个月以内者居多,占到54.84%。骨转移部位以脊柱、骨盆、股骨、肋骨居多,且骨转移灶大都为多发。108例骨转移灶疼痛患者经唑来膦酸治疗后VAS评分为0~4(1.31±1.07)分,较治疗前差异有统计学意义(P0.01)。结论骨转移癌应争取早期诊断,采取综合治疗,以期为患者减轻痛苦,改善生存质量,延长生存期。
[Abstract]:Objective to explore and analyze the clinical features of bone metastatic carcinoma and to improve the diagnosis and treatment of bone metastatic carcinoma. Methods the clinical data of 217 patients with bone metastases were retrospectively analyzed, and the clinical features of primary tumor, age distribution, initial symptoms, onset time, site of bone metastasis were summarized. Visual analogue score (VAS) was used to evaluate the difference of pain in bone metastases before and after zoledronic acid treatment. Results the majority of patients with metastatic bone cancer were male, the ratio of male to female was 1.28: 1. The primary tumors were lung cancer (51.61%) and breast cancer (15.67%). Most of the patients with metastatic carcinoma of bone were initially unwell with different degrees of pain, and a few with dysfunction, pathological fracture, local mass as the first symptom, and were found by accident. The onset time was less than 3 months, accounting for 54.84. The main sites of bone metastasis were spinal column, pelvis, femur and rib, and most of them had multiple bone metastases. The VAS score of 108 patients with pain of bone metastases was 0.31 卤1.07 after zoledronic acid treatment. The difference was statistically significant compared with that before treatment (P0.01). Conclusion early diagnosis and comprehensive treatment should be taken in order to alleviate the pain, improve the quality of life and prolong the survival time for patients with bone metastases.
【作者单位】：华北理工大学附属医院骨科;河北省唐山市第二医院骨病科;
【分类号】：R738

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