右美托咪定对甲状腺手术患者呛咳反应的影响

发布时间：2018-12-16 13:53

【摘要】：目的探讨右美托咪定对甲状腺手术患者呛咳反应的影响。方法择期全麻下甲状腺肿瘤手术患者118例,男43例,女75例,年龄18~65岁,BMI 18~30kg/m2,ASAⅠ或Ⅱ级,采用随机数字表法分为两组,每组59例。D组在手术开始时持续静脉泵注右美托咪定0.4μg·kg~(-1)·h~(-1)至手术结束,C组在手术开始时持续静脉泵注等容量生理盐水至手术结束。观察患者全麻恢复期间呛咳发生情况,记录患者术后24、48h引流量,以及心动过速、低血压、高血压、心动过缓等不良反应的发生情况。结果 D组全麻恢复期间呛咳发生率明显低于C组(10.1%vs 30.5%,P0.05),D组术后第1个24h[(62.3±26.8)ml vs(78.6±30.1)ml,P0.05]、第2个24h[(28.0±12.5)ml vs(37.5±18.6)ml,P0.05]引流量明显少于C组;D组围术期心动过速发生率明显低于C组(3.4%vs 23.7%,P0.05)。结论术中持续输注右美托咪定0.4μg·kg-1·h-1能够有效减轻甲状腺手术患者全麻恢复期间的呛咳反应,降低患者术后出血的风险。
[Abstract]:Objective to investigate the effect of dexmetomidine on cough response in patients undergoing thyroid surgery. Methods one hundred and eighteen patients (43 males and 75 females) with thyroid neoplasms undergoing elective general anesthesia were divided into two groups by random digital table. The patients were aged 1865 years, with BMI 1830kg / m2 ASA 鈪，

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