金天格胶囊联合非甾体镇痛剂治疗膝关节退行性关节炎的临床研究

发布时间：2018-12-18 08:15

【摘要】：目的观察金天格胶囊联合非甾体抗炎镇静剂对膝关节退行性关节炎的治疗效果,为膝关节退行性关节炎的治疗提供临床依据。方法选取骨科门诊病人膝关节退行性关节炎患者120例,并随机分为3组,每组40人;A组口服金天格胶囊即为骨保护剂组,B组口服洛索洛芬钠片即(glucosamine hydrochloride)为非甾体抗炎镇痛剂组,C组联合口服金天格胶囊及洛索洛芬钠片即为骨保护剂及非甾体镇痛剂组。每组病人均进行为期12 w的治疗,并分别在治疗前、治疗中及治疗后进行临床疗效统计及治疗前后症状改善率比较。结果骨保护剂联合非甾体抗炎镇痛剂组Lequesne指数及治愈率明显高于其他两组,差异有统计学意义(P0.05);骨保护剂组与非甾体抗炎镇痛剂组差异无统计学意义(P0.05)。结论单独应用金天格胶囊治疗膝骨性关节炎效果与洛索洛芬钠片相当,金天格胶囊联合洛索洛芬钠片效果优于单独使用金天格胶囊或洛索洛芬钠片,且副反应少,作用持久。
[Abstract]:Objective to observe the therapeutic effect of Jintiangge capsule combined with nonsteroidal anti-inflammatory sedative on degenerative arthritis of knee joint and provide clinical basis for the treatment of degenerative arthritis of knee joint. Methods 120 patients with knee joint degenerative arthritis in orthopedic outpatient department were randomly divided into 3 groups, 40 in each group. Group A was treated with bone protectant, group B was treated with (glucosamine hydrochloride) as non-steroidal anti-inflammatory analgesics, group C was combined with Jintianger capsule and losuprofen sodium tablets as bone protectant and nonsteroidal analgesics. The patients in each group were treated for 12 weeks, and the clinical curative effect and symptom improvement rate were compared before, during and after treatment respectively. Results the Lequesne index and cure rate of bone protectant combined with non-steroidal anti-inflammatory analgesic group were significantly higher than those of other two groups (P0.05), but there was no significant difference between bone protectant group and non-steroidal anti-inflammatory analgesic group (P0.05). Conclusion the efficacy of Jintiangge capsule alone in treating knee osteoarthritis is equivalent to that of losuprofen sodium tablet. The effect of Jintianger capsule combined with losuprofen sodium tablet is better than that of Jintianger capsule or losuprofen sodium tablet alone, with less side effects and lasting effect.
【作者单位】：天津医科大学研究生院;天津医科大学总医院骨科;
【基金】：国家自然科学基金资助项目(81272013)
【分类号】：R684.3

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