Lenke3型成人特发性脊柱侧凸有限元模型的参数修正及有效性验证
发布时间：2018-12-19 18:35
【摘要】：背景:作者利用Mimics等有限元软件成功建立了Lenke3型成人特发性脊柱有限元模型,但模型是否最大程度的符合个体化患者的真实情况,需要进一步进行模型修正及有效性验证。目的:利用有限元分析软件对Lenke3型成人特发性脊柱有限元模型进行修正及有效性验证。方法:根据Lenke3型成人特发性脊柱侧凸模型的特点,利用三因素三水平正交试验优化有限元模型,使模型特点最大程度的接近真实,通过模拟左右侧屈实验,分段加载选取T_1-T_4、T_5-T_8、L_6-S_1(骶椎腰化)节段分别模拟左右侧屈、前屈后伸,左右旋转活动度与体外Busscher、Yamamoto实验进行对比研究,多方位验证模型有效性。结果与结论:(1)根据正交实验计算各因素各水平的平均差异和极差R,最后计算出A1B2C3的最佳组合可使模拟实验结果最符合个体的真实情况,使得有限元模拟实验结果与患者临床真实情况的差异最小。临床侧屈试验和参数修正前模型模拟的Cobb角度的变化差异值为54.44°,经过参数修正后模型的差异值减小为2.11°。修正后模型各侧凸Cobb角的最大差异为4.29°;(2)修正后的模型与仰卧左右侧屈位X射线片对比,2组配对数据均服从正态分布,故利用配对t检验进行计算,左侧屈时,P=0.082,P0.05;右侧屈时,P=0.421,P0.05;仰卧位P=0.160,P0.05;(3)修正后的模型T_1-T_4节段各个方向的ROM:左屈3.25°,右屈3.32°,前屈2.52°,后伸2.89°,左侧旋转3.73°,右侧旋转3.76°,T5-T8节段各个方向的ROM:左屈1.39°,右屈1.43°,前屈1.35°,后伸1.34°,左旋2.09°,右旋2.11°;L_6/S_1节段各个方向的ROM:左屈5.17°,右屈5.19°,前屈8.92°,后伸7.35°,左旋1.41°,右旋1.42°,获得的结果与Busscher及Yamamoto等的实验结果进行比较,结果基本吻合;(4)结果提示,通过对初始模型进行参数修正处理,使得模型与患者真实的材料属性基本符合。修正后的模型具有较好的可靠性和有效性,为下一步模拟临床手术操作提供了有效的数据平台。
[Abstract]:Background: the author has successfully established the Lenke3 type adult idiopathic spinal column finite element model by using Mimics and other finite element software, but whether the model accords with the real situation of individual patients to the greatest extent, needs to be further revised and validated. Objective: to modify and validate the Lenke3 model of adult idiopathic spinal column by finite element analysis software. Methods: according to the characteristics of Lenke3 model of adult idiopathic scoliosis, the finite element model was optimized by using three factors and three levels of orthogonal experiments. Segmental loading and selecting T _ 1-T _ 4 and T _ 5-T _ 5 _ S _ 1 (sacral lumbar vertebrae) segment to simulate the flexion of left and right side, flexion and extension of anterior flexion, rotation activity of left and right and Busscher,Yamamoto experiment in vitro respectively, The validity of the model is verified in multiple directions. Results and conclusions: (1) based on the orthogonal experiment, the average differences and ranges of each factor level were calculated. Finally, the optimal combination of A1B2C3 was calculated to make the simulation results best accord with the real situation of individual. The difference between the finite element simulation results and the patient's clinical reality is minimized. The variation of Cobb angle was 54.44 掳in the model before clinical flexion test and parameter modification, and the difference value decreased to 2.11 掳after parameter modification. The maximum difference of Cobb angle of the modified model is 4.29 掳. (2) the modified model was compared with the supine lateral and right flexion X-ray films. The data of the two groups were normally distributed, so the paired t test was used to calculate, the left flexion, P0. 082, P0. 05, the right, P0. 421, P0. 05, and the right, P0. 421, P0. 05, respectively. The supine position was 0.160 (P0.05); (3) the ROM: of the modified T_1-T_4 segment was 3.25 掳left flexion, 3.32 掳right flexion, 2.52 掳forward flexion, 2.89 掳extension, 3.73 掳left rotation and 3.76 掳right rotation. ROM: in all directions of T5-T8 segment was 1.39 掳left flexion, 1.43 掳right flexion, 1.35 掳forward flexion, 1.34 掳extension, 2.09 掳left lateral flexion and 2.11 掳dextral flexion. The results of left flexion 5.17 掳, right flexion 5.19 掳, forward flexion 8.92 掳, extension 7.35 掳, left lateral 1.41 掳, right-hand 1.42 掳in all directions of L_6/S_1 segment were compared with those of Busscher and Yamamoto. The results were basically consistent. (4) the results suggest that the model is basically consistent with the patient's real material properties by modifying the parameters of the initial model. The modified model has good reliability and effectiveness, and provides an effective data platform for the next step to simulate the clinical operation.
【作者单位】： 内蒙古医科大学第二附属医院;重庆医科大学附属第一医院骨科;内蒙古医科大学附属医院;
【基金】：内蒙古自治区自然科学基金(2016MS08141)~~
【分类号】：R682.3
，
本文编号：2387297
[Abstract]:Background: the author has successfully established the Lenke3 type adult idiopathic spinal column finite element model by using Mimics and other finite element software, but whether the model accords with the real situation of individual patients to the greatest extent, needs to be further revised and validated. Objective: to modify and validate the Lenke3 model of adult idiopathic spinal column by finite element analysis software. Methods: according to the characteristics of Lenke3 model of adult idiopathic scoliosis, the finite element model was optimized by using three factors and three levels of orthogonal experiments. Segmental loading and selecting T _ 1-T _ 4 and T _ 5-T _ 5 _ S _ 1 (sacral lumbar vertebrae) segment to simulate the flexion of left and right side, flexion and extension of anterior flexion, rotation activity of left and right and Busscher,Yamamoto experiment in vitro respectively, The validity of the model is verified in multiple directions. Results and conclusions: (1) based on the orthogonal experiment, the average differences and ranges of each factor level were calculated. Finally, the optimal combination of A1B2C3 was calculated to make the simulation results best accord with the real situation of individual. The difference between the finite element simulation results and the patient's clinical reality is minimized. The variation of Cobb angle was 54.44 掳in the model before clinical flexion test and parameter modification, and the difference value decreased to 2.11 掳after parameter modification. The maximum difference of Cobb angle of the modified model is 4.29 掳. (2) the modified model was compared with the supine lateral and right flexion X-ray films. The data of the two groups were normally distributed, so the paired t test was used to calculate, the left flexion, P0. 082, P0. 05, the right, P0. 421, P0. 05, and the right, P0. 421, P0. 05, respectively. The supine position was 0.160 (P0.05); (3) the ROM: of the modified T_1-T_4 segment was 3.25 掳left flexion, 3.32 掳right flexion, 2.52 掳forward flexion, 2.89 掳extension, 3.73 掳left rotation and 3.76 掳right rotation. ROM: in all directions of T5-T8 segment was 1.39 掳left flexion, 1.43 掳right flexion, 1.35 掳forward flexion, 1.34 掳extension, 2.09 掳left lateral flexion and 2.11 掳dextral flexion. The results of left flexion 5.17 掳, right flexion 5.19 掳, forward flexion 8.92 掳, extension 7.35 掳, left lateral 1.41 掳, right-hand 1.42 掳in all directions of L_6/S_1 segment were compared with those of Busscher and Yamamoto. The results were basically consistent. (4) the results suggest that the model is basically consistent with the patient's real material properties by modifying the parameters of the initial model. The modified model has good reliability and effectiveness, and provides an effective data platform for the next step to simulate the clinical operation.
【作者单位】： 内蒙古医科大学第二附属医院;重庆医科大学附属第一医院骨科;内蒙古医科大学附属医院;
【基金】：内蒙古自治区自然科学基金(2016MS08141)~~
【分类号】：R682.3
，
本文编号：2387297
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