全髋关节置换围手术期联用氨甲环酸止血的安全性及有效性

发布时间：2019-01-23 20:48

【摘要】：目的探讨静脉联合关节腔内注射氨甲环酸对全髋关节置换围手术期出血及深静脉血栓形成的影响。方法选择行单侧全髋关节置换的102例患者进行研究。采用随机数字表法将其分为4组:A组26例,静脉联合关节腔内注射氨甲环酸;B组26例,静脉注射氨甲环酸;C组25例,关节腔内注射氨甲环酸;D组25例,未使用氨甲环酸。比较4组术中失血量、术后引流量、术后总失血量、血红蛋白含量、输血量及深静脉血栓发生率。结果术后引流量、术后总失血量、血红蛋白含量、输血量,A组优于B、C组,B组优于C、D组,C组优于D组,差异均有统计学意义(P0.05)。4组患者术中失血量及深静脉血栓发生率差异无统计学意义(P0.05)。结论静脉联合关节腔内注射氨甲环酸能明显降低全髋关节置换围手术期失血量,并且不增加深静脉血栓形成发生的风险,较单独使用氨甲环酸效果更好。
[Abstract]:Objective to investigate the effect of intraarticular injection of ammonia cycline on perioperative hemorrhage and deep venous thrombosis in total hip arthroplasty (THR). Methods 102 patients with unilateral total hip replacement were studied. They were randomly divided into four groups: group A (n = 26), group B (n = 26), group C (n = 25), intraarticular injection of aminoformic acid; Group D, 25 cases, did not use carbonic acid. The blood loss, postoperative drainage, total blood loss, hemoglobin content, blood transfusion volume and the incidence of deep venous thrombosis were compared among the four groups. Results postoperative drainage, total blood loss, hemoglobin content and blood transfusion volume in group A were better than those in group B, group B and group C were superior to group C and group D, respectively. The difference was statistically significant (P0.05). There was no significant difference in intraoperative blood loss and the incidence of deep venous thrombosis in the 4 groups (P0.05). Conclusion intravenous and intraarticular injection of aminocylic acid can significantly reduce blood loss in perioperative period of total hip replacement and does not increase the risk of deep venous thrombosis.
【作者单位】：南宁市第二人民医院脊柱外科;
【基金】：广西壮族自治区卫计委科研课题(编号:Z2014459)
【分类号】：R687.4

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