胶原蛋白海绵控制髋关节置换术后出血的应用

发布时间：2019-02-09 14:05

【摘要】：[目的]探讨胶原蛋白海绵在控制全髋关节置换术后出血中的有效性与安全性。[方法]选取2014年8月~2015年8月行髋关节置换术的患者150例,随机分为两组:胶原蛋白海绵组75例,使用胶原蛋白海绵;空白对照组75例,未予使用。记录每个患者术后可见失血量、术中失血量、总失血量、术前术后血红蛋白值、两组中的输血患者数及并发症等。[结果]胶原蛋白海绵组术后可见失血量为(364.01±38.19)ml,空白对照组为(380.08±40.41)ml,差异无统计学意义;胶原蛋白海绵组术中失血量为(481.70±82.92)ml,空白对照组为(497.28±90.57)ml,差异无统计学意义;两组总失血量分别为(1 250.73±266.10)ml和(1 552.69±276.32)ml,差异有统计学意义;两组术后24 h血红蛋白下降值分别为(34.20±3.79)g/L、(42.64±5.12)g/L,差异有统计学意义;两组分别有22例和37例患者术后输血,差异有统计学意义;两组各有1例患者切口近端表浅皮肤坏死合并感染,空白对照组中有1例发生深静脉血栓,差异无统计学意义(P=1.000)。[结论]医用胶原蛋白海绵可以有效降低THA的术后失血量。
[Abstract]:Objective: to investigate the efficacy and safety of collagen sponge in controlling bleeding after total hip arthroplasty. [methods] 150 patients undergoing hip arthroplasty from August 2014 to August 2015 were randomly divided into two groups: collagen sponge group (n = 75) and blank control group (n = 75). The blood loss, intraoperative blood loss, total blood loss, preoperative and postoperative hemoglobin values, the number of blood transfusion patients and complications were recorded. [results] the blood loss was (364.01 卤38.19) ml, in the collagen sponge group and (380.08 卤40.41) ml, in the control group. The amount of blood loss in collagen sponge group was (481.70 卤82.92) ml, and that in control group was (497.28 卤90.57) ml,. The total blood loss of the two groups was (1 250.73 卤266.10) ml and (1 552.69 卤276.32) ml, respectively. The decrease of hemoglobin in the two groups was (34.20 卤3.79) g / L and (42.64 卤5.12) g / L, respectively. One patient in each group had superficial skin necrosis and infection at the proximal end of incision, while one patient in the blank control group had deep venous thrombosis (P < 1.000). [conclusion] Medical collagen sponge can effectively reduce postoperative blood loss of THA.
【作者单位】：上海交通大学医学院附属新华医院崇明分院骨科;第二军医大学附属长征医院骨科;陆军军官学院医院;
【基金】：崇明县科学技术委员会项目(编号:CKY2015-03),胶原蛋白海绵控制老年人髋关节置换术后出血的应用研究
【分类号】：R687.4

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