阿莫西林-双氯西林联合治疗皮肤蜂窝织炎伴高热患者22例临床研究
发布时间：2019-02-13 14:27
【摘要】：目的分析阿莫西林-双氯西林联合治疗蜂窝组织炎伴高热患者的临床疗效,为蜂窝组织炎患者临床治疗方案选择提供参考。方法对医院收治的22例蜂窝组织炎伴高热患者采用阿莫西林-双氯西林联合治疗,同时对患者病变部位取样进行病原学分析,分析患者阿莫西林-双氯西林联合治疗前后临床症状改善情况、炎症细胞因子(IL-6、IL-8、IL-10、超敏C-反应蛋白)的改善情况,根据患者临床治疗的疗效及病原学-药敏分析结果调整敏感抗菌药物治疗,统计患者调整抗菌药物治疗情况,分析阿莫西林-双氯西林联合治疗蜂窝组织炎伴高热患者的临床价值。结果 22例患者临床症状为典型的蜂窝组织炎症状;22例患者患部擦拭取样或脓液进行病原菌培养,共分离出25株病原菌,其中革兰阳性菌17株(均为金黄色葡萄球菌),革兰阴性菌6株(溶血性链球菌5株,硝化菌1株),真菌2株;22例患者经阿莫西林-双氯西林联合治疗后,20例患者的临床症状明显改善,2例患者改用敏感抗菌药物后临床症状改善;患者治疗后炎症细胞因子(IL-6、IL-8、IL-10、超敏C-反应蛋白)均较治疗前明显降低(P0.05),IL-10较治疗前明显升高(P0.05),2例患者治疗3d后临床症状无明显改善,调整敏感抗菌药物治疗后,获得较好疗效。结论蜂窝组织炎伴高热患者临床较为少见,阿莫西林联合双氯西林对其进行经验性治疗,可有效涵盖病原菌谱,疗效较好,使患者得到及时治疗,具有较高的临床价值。
[Abstract]:Objective to analyze the clinical effect of amoxicillin combined with dicloxicillin in the treatment of cellulitis with high fever, and to provide reference for clinical treatment of cellulitis. Methods 22 patients with cellulitis and high fever were treated with amoxicillin and dicloxicillin. To analyze the improvement of clinical symptoms and inflammatory cytokines (IL-6,IL-8,IL-10, hypersensitive C-reactive protein) before and after combined treatment with amoxicillin and dicloxicillin. According to the curative effect of clinical treatment of patients and the results of etiology-drug sensitivity analysis, we adjusted the treatment of sensitive antimicrobial agents and counted the situation of patients adjusting the treatment of antimicrobial agents. To analyze the clinical value of amoxicillin-dicloxicillin in the treatment of cellulitis with high fever. Results the clinical symptoms of 22 patients were typical cellulitis. A total of 25 strains of pathogenic bacteria were isolated, including 17 Gram-positive bacteria (all Staphylococcus aureus), 6 Gram-negative bacteria (hemolytic streptococcus 5, 1 nitrifying bacterium). 2 strains of fungi; After combined treatment with amoxicillin and dicloxicillin, the clinical symptoms of 20 patients were significantly improved, and the clinical symptoms of 2 patients were improved after the use of sensitive antimicrobial agents. After treatment, the inflammatory cytokines (IL-6,IL-8,IL-10, hypersensitive C- reactive protein) were significantly lower than those before treatment (P0.05), IL-10 was significantly higher than that before treatment (P0.05). After 3 days of treatment, the clinical symptoms of 2 patients were not obviously improved, and good results were obtained after adjusting sensitive antimicrobial agents. Conclusion Cellular histitis with high fever is rare in clinic. The empirical treatment of amoxicillin combined with dicloxicillin can effectively cover the spectrum of pathogenic bacteria and has a good curative effect. It makes the patients get timely treatment and has higher clinical value.
【作者单位】： 瑞安市人民医院临床药学室;
【基金】：浙江省社发基金资助项目(2015zj00034)
【分类号】：R632.4
，
本文编号：2421644
[Abstract]:Objective to analyze the clinical effect of amoxicillin combined with dicloxicillin in the treatment of cellulitis with high fever, and to provide reference for clinical treatment of cellulitis. Methods 22 patients with cellulitis and high fever were treated with amoxicillin and dicloxicillin. To analyze the improvement of clinical symptoms and inflammatory cytokines (IL-6,IL-8,IL-10, hypersensitive C-reactive protein) before and after combined treatment with amoxicillin and dicloxicillin. According to the curative effect of clinical treatment of patients and the results of etiology-drug sensitivity analysis, we adjusted the treatment of sensitive antimicrobial agents and counted the situation of patients adjusting the treatment of antimicrobial agents. To analyze the clinical value of amoxicillin-dicloxicillin in the treatment of cellulitis with high fever. Results the clinical symptoms of 22 patients were typical cellulitis. A total of 25 strains of pathogenic bacteria were isolated, including 17 Gram-positive bacteria (all Staphylococcus aureus), 6 Gram-negative bacteria (hemolytic streptococcus 5, 1 nitrifying bacterium). 2 strains of fungi; After combined treatment with amoxicillin and dicloxicillin, the clinical symptoms of 20 patients were significantly improved, and the clinical symptoms of 2 patients were improved after the use of sensitive antimicrobial agents. After treatment, the inflammatory cytokines (IL-6,IL-8,IL-10, hypersensitive C- reactive protein) were significantly lower than those before treatment (P0.05), IL-10 was significantly higher than that before treatment (P0.05). After 3 days of treatment, the clinical symptoms of 2 patients were not obviously improved, and good results were obtained after adjusting sensitive antimicrobial agents. Conclusion Cellular histitis with high fever is rare in clinic. The empirical treatment of amoxicillin combined with dicloxicillin can effectively cover the spectrum of pathogenic bacteria and has a good curative effect. It makes the patients get timely treatment and has higher clinical value.
【作者单位】： 瑞安市人民医院临床药学室;
【基金】：浙江省社发基金资助项目(2015zj00034)
【分类号】：R632.4
，
本文编号：2421644
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