髋臼盖治疗家兔髋臼发育不良的实验研究

发布时间：2019-03-04 15:31

【摘要】：目的:探讨髋臼盖加植骨治疗实验家兔髋臼发育不良的效果,为临床应用髋臼盖治疗髋臼发育不良提供实验依据。方法:健康实验用新西兰家兔15只,将双侧髋关节制作成髋臼发育不良模型,左右自身对照,选择左侧髋关节为实验组,采用髋臼盖加自体松质骨植骨矫正髋臼发育不良,右侧髋关节为对照组,采用克氏针固定自体髂骨块加盖矫正髋臼发育不良。术后观察家兔的一般情况、步态,并在4、8、12周各处死5只家兔进行髋关节植骨标本大体和组织学观察,了解植骨融合情况,并对髋关节软骨修复进行改良Pineda评分。结果:实验家兔术后均存活,伤口均一期愈合。双侧后肢步态无差异。所有家兔处死后X线检查髋关节均无脱位,髋臼对股骨头包容良好,未见内固定物松动、脱落和断裂。大体标本和组织学观察实验组植骨与髋骨的联接愈合比对照组更早,术后12周两组均能植骨愈合、髋臼关节软骨面修复。比较两种方法修复髋关节软骨Pineda评分,实验组的基质染色、表面平整度、与宿主结合及总分值与对照组比较差异非常显著(p0.0001),两组在细胞形态间存在差异(p0.05),但软骨厚度差异不显著(p0.05)。结论:1.髋臼盖固定植骨块和克氏针固定植骨块都可用于修复实验家兔髋臼发育不良。2.髋臼盖加植骨比克氏针固定植骨块修复实验家兔髋臼发育不良的植骨融合效果更好。
[Abstract]:Aim: to investigate the effect of acetabular cover plus bone graft in the treatment of acetabular dysplasia in rabbits, and to provide experimental basis for the clinical application of acetabular cover in the treatment of acetabular dysplasia. Methods: fifteen New Zealand rabbits were used in the healthy experiment. Bilateral hip joint was made into acetabular dysplasia model, left hip joint was selected as experimental group, acetabular cover and autogenous cancellous bone graft were used to correct acetabular dysplasia. The right hip joint was treated with Kirschner wire fixation with autogenous iliac bone mass and cover to correct acetabular dysplasia. The general condition and gait of rabbits were observed after operation, and 5 rabbits were killed at 4,8,12 weeks after operation to observe the gross and histological changes of hip graft specimens, to understand the fusion of bone graft, and to improve the Pineda score of cartilage repair of hip joint. Results: all the rabbits survived and the wounds healed in one stage. There was no difference in gait between the two hind limbs. All rabbits were killed and X-ray examination showed no dislocation of hip joint, acetabular inclusion of femoral head, no loosening, shedding and breaking of internal fixator. Gross specimen and histological observation the union healing of bone graft and hip bone in the experimental group was earlier than that in the control group. At 12 weeks after operation, both groups could heal and repair the cartilage surface of acetabular joint. There were significant differences in Pineda score, matrix staining, surface flatness, binding to host and total score between the two groups (p0.0001), and there was significant difference between the two groups in cell morphology (p0.05), and there was a significant difference between the two groups in cell morphology (p0.05), compared with the control group (p0.0001). However, there was no significant difference in cartilage thickness (p0.05). Conclusions: 1. Acetabular cover fixation and Kirschner wire fixation can be used to repair acetabular dysplasia in experimental rabbits. The fusion effect of acetabular cover and bone graft was better than that of Kirschner wire fixation in experimental rabbits with acetabular dysplasia.
【学位授予单位】：南华大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R687.3

【相似文献】