乳腺癌根治术后感染患者细胞因子及急性时相反应蛋白表达的研究

发布时间：2019-03-22 06:20

【摘要】：目的观察乳腺癌根治术后感染患者的相关细胞因子与急性时相反应蛋白的水平变化情况,为有效控制乳腺癌术后感染提供依据。方法选取2010年1月-2016年11月于医院接受治疗的68例乳腺癌根治术后感染的患者为观察组,选取同期68例乳腺癌术后非感染患者为对照组,比较两组患者的白细胞介素、干扰素、肿瘤坏死细胞因子及急性时相反应蛋白中的C-反应蛋白(CPR)、α2-巨球蛋白(α2-M)、转铁蛋白(TF)、结合珠蛋白(HP)、铜蓝蛋白(CP)的水平变化。结果观察组的白细胞介素指标(IL-2、IL-4、IL-8、IL-10)均显著高于对照组(P0.05);干扰素指标(IFN-α、IFN-r)显著高于对照组(P0.05);肿瘤坏死因子(TNF-α、TNF-β)比对照组水平略高(P0.05);观察组CPR、α2-M、HP、CP的表达水平显著高于对照组,而TF较对照组水平略低(P0.05)。结论乳腺癌根治术后感染患者的细胞因子和急性时相反应蛋白水平有明显的变化,并且这些指标的异常表达可能参与了感染的炎性反应。
[Abstract]:Aim to observe the changes of cytokines and acute reaction protein levels in patients with postoperative infection after radical mastectomy, so as to provide evidence for effective control of postoperative infection in patients with breast cancer. Methods 68 patients with postoperative infection after radical mastectomy were selected from January 2010 to November 2016 in hospital as the observation group, 68 patients with non-infection after breast cancer operation were selected as the control group in the same period, and the interleukin levels in the two groups were compared. Levels of interferon, tumor necrosis cytokines and C-reactive protein (CPR), 伪 2-macroglobulin (伪 2-M), transferrin (TF), binding globin (HP), ceruloplasmin (CP) in acute response proteins. Results the levels of IL-2,IL-4,IL-8,IL-10 and IFN-r in the observation group were significantly higher than those in the control group (P0.05), and the levels of interferon 伪 (IFN-r) in the observation group were significantly higher than those in the control group (P0.05). The level of TNF- 伪 (TNF- 尾) was slightly higher in the observation group than in the control group (P0.05), and the expression of CPR, 伪 2-M, HP, CP in the observation group was significantly higher than that in the control group, while the level of TF was slightly lower than that in the control group (P0.05). Conclusion there are significant changes in cytokines and acute response protein levels in patients with infection after radical mastectomy, and the abnormal expression of these indexes may be involved in the inflammatory response of infection.
【作者单位】：河南省人民医院乳腺外一科;
【基金】：河南省科技计划基金资助项目(142300410388和132300410048) 河南省医学科技攻关项目(201602169)
【分类号】：R737.9

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