细胞疗法是修复退变椎间盘最有前景的技术

发布时间：2019-04-21 16:00

【摘要】：背景:目前临床上治疗椎间盘退变性疾病的方法,无论是手术方案还是非手术方案,均不能减缓或逆转椎间盘退变的进程,远期疗效不满意。近年来随着再生医学与组织工程的不断发展,运用细胞疗法修复退变的椎间盘得到了越来越多的研究者的关注。目的:综述细胞疗法,特别是干细胞疗法修复退变椎间盘的研究现状及面临的一些问题。方法:通过计算机在PubMed数据库中检索近5年的相关文献,检索的时间设置为2011年1月至2016年1月。检索的英文主题词为"stem cell;intervertebral disk degeneration。"筛选出内容与细胞疗法修复退变椎间盘相关的文献,着重选取最新的实验及临床研究成果。结果与结论:初检获得文献205篇,最终甄选出符合纳入标准的50篇文献进行综述。干细胞与载体的结合物被注射进退变的椎间盘,从而发挥修复退变椎间盘的作用。这种方法得到了越来越多的研究者的认可,被认为未来最具有潜力的治疗方法。但是,相关的临床研究却少之又少,其临床的安全性需要进一步的评估。
[Abstract]:Background: at present, the clinical treatment of intervertebral disc degeneration disease, whether surgical or non-operative, can not slow down or reverse the progress of intervertebral disc degeneration, and the long-term effect is not satisfactory. In recent years, with the development of regenerative medicine and tissue engineering, more and more researchers pay attention to the application of cell therapy in the repair of degenerative intervertebral discs. Aim: to review the current status and problems of cell therapy, especially stem cell therapy, in the repair of degenerative intervertebral discs. Methods: the related literatures of recent 5 years were searched in PubMed database by computer. The retrieval time was from January 2011 to January 2016. The English subject word retrieved is "stem cell;intervertebral disk degeneration." The literatures related to cell therapy for the repair of degenerative intervertebral discs were screened, and the latest experimental and clinical results were emphatically selected. Results & conclusion: 205 papers were obtained from the preliminary examination, and 50 articles which met the inclusion criteria were selected for review. The combination of stem cells and vectors is injected into the degenerated disc to repair the degenerative disc. This method has been accepted by more and more researchers and is regarded as the most potential therapy in the future. However, there are few clinical studies, and its clinical safety needs to be further evaluated.
【作者单位】：南京中医药大学;南京中医药大学附属中西医结合医院;江苏省中医药研究院;
【基金】：江苏省科技项目(BK20151604)~~
【分类号】：R681.5

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