脂肪因子基因多态性与腹主动脉瘤的相关性研究
发布时间：2019-05-21 11:12
【摘要】：目的 脂肪因子在AAA的进展中起重要作用。研究表明脂肪因子单核苷酸多肽性与心血管疾病相关,但在AAA中研究尚未见报道。因此,本研究旨在探讨+276G/T和-420C/G在中国人群AAA中的意义方法 采用病例对照研究设计,AAA患者155例为病例组,按照年龄、性别配对条件,对照组同期纳入310例非AAA患者。采用质谱分析法(MassArray system)测定DNA样本+276G/T和-420C/G两位点。探讨基因型和AAA之间的关系研究采用回归分析法,根据实验室检测结果及临床特征对人群进行分层分析。结果+276G/T和抵抗素RETN-420CG基因多态性与AAA的发生无关。-420GG基因型较(CG+CC)可增加AAA发展为大AAA的风险(OR=5.84,95%CI1.50,22.68;p=0.011).另外,GG基因型可增加正常人群发展为小AAA的风险,但这种影响在调整吸烟、饮酒等危险因素后消失。结论 脂联素SNP+276与AAA的进展无关。抵抗素-420CG与AAA的发生无相关性,-420GG基因型与AAA的进展有关,有待进一步研究证实。
[Abstract]:Objective Fat factor plays an important role in the progress of AAA. Studies have shown that adipose factor single nucleotides polypeptide is associated with cardiovascular disease, but it has not been reported in AAA. Therefore, the purpose of this study was to explore the significance of 276G/T and-420C/G in AAA of Chinese population. A case-control study was designed. 155 patients with AAA were selected as case group and matched according to age and sex. In the control group, 310 patients with non-AAA were included in the control group at the same time. The 276G/T and-420C/G sites of DNA samples were determined by mass spectrometry (MassArray system). To explore the relationship between genotype and AAA, regression analysis was used to analyze the population according to the results of laboratory test and clinical characteristics. Results the polymorphism of 276G/T and resistin RETN-420CG gene was not related to the occurrence of AAA.-420GG genotype increased the risk of AAA developing into large AAA (OR=5.84,95%CI1.50,22.68;p=0.011) compared with (CG CC). In addition, GG genotype increased the risk of developing small AAA in normal people, but this effect disappeared after adjusting for risk factors such as smoking and drinking. Conclusion adiponectin SNP 276 has nothing to do with the progress of AAA. There was no correlation between resistin-420CG and the occurrence of AAA. The genotype of-420GG was related to the progress of AAA, which needed to be confirmed by further study.
【学位授予单位】：中国人民解放军医学院
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R654.3
本文编号：2482063
[Abstract]:Objective Fat factor plays an important role in the progress of AAA. Studies have shown that adipose factor single nucleotides polypeptide is associated with cardiovascular disease, but it has not been reported in AAA. Therefore, the purpose of this study was to explore the significance of 276G/T and-420C/G in AAA of Chinese population. A case-control study was designed. 155 patients with AAA were selected as case group and matched according to age and sex. In the control group, 310 patients with non-AAA were included in the control group at the same time. The 276G/T and-420C/G sites of DNA samples were determined by mass spectrometry (MassArray system). To explore the relationship between genotype and AAA, regression analysis was used to analyze the population according to the results of laboratory test and clinical characteristics. Results the polymorphism of 276G/T and resistin RETN-420CG gene was not related to the occurrence of AAA.-420GG genotype increased the risk of AAA developing into large AAA (OR=5.84,95%CI1.50,22.68;p=0.011) compared with (CG CC). In addition, GG genotype increased the risk of developing small AAA in normal people, but this effect disappeared after adjusting for risk factors such as smoking and drinking. Conclusion adiponectin SNP 276 has nothing to do with the progress of AAA. There was no correlation between resistin-420CG and the occurrence of AAA. The genotype of-420GG was related to the progress of AAA, which needed to be confirmed by further study.
【学位授予单位】：中国人民解放军医学院
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R654.3
【参考文献】
相关期刊论文 前2条
1 汝颖,马猛,马腾,王长江,王佑民,章秋,陈明卫,杨明功;脂联素基因SNP276多态性与冠心病及胰岛素敏感性的相关性[J];中国循环杂志;2005年05期
2 ;High Serum Resistin Level may be an Indicator of the Severity of Coronary Disease in Acute Coronary Syndrome[J];Chinese Medical Sciences Journal;2009年03期
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