急性颅脑损伤患者神经颗粒素测定的临床意义
发布时间：2019-05-29 23:09
【摘要】：目的探讨神经颗粒素(neurograinin,NG)作为急性颅脑损伤(traumatic injury,TBI)患者外周循环标志物的临床意义。方法收集无锡市101医院急诊收治的TBI患者71例,经头颅电子计算机断层扫描(CT)或磁共振成像(MRI)检查确诊,以85例无锡市中医医院体检正常者作为正常对照组。用ELISA双抗体夹心法检测TBI患者和正常对照组外周血中NG水平,采用凝固法检测凝血酶原时间(PT)、纤维蛋白原(Fib),采用胶乳增强免疫比浊法检测C反应蛋白(CRP),用全自动五分类血液分析仪检测血小板(PLT)数量。结果 TBI患者血清NG水平为850.51(647.96,962.11)pg/m L,正常对照组血清NG水平为612.44(534.44,733.9)pg/m L,TBI患者血清NG水平显著高于正常对照组(U=36.146,P=0.000)。中型和重型TBI患者NG水平高于轻型TBI患者,但差异无统计学意义(P0.05)。原发性颅脑损伤组血清NG水平高于继发性颅脑损伤组,但差异无统计学意义(P0.05)。TBI患者的年龄、性别、Glasgow积分与血清NG水平无直接关系,而PLT、PT、国际化标准比率(INR)及CRP则是影响NG的主要因素。结论 NG在TBI患者血清中的表达升高,该指标联合凝血功能检测可能对判断TBI患者严重程度和进展具有一定意义。
[Abstract]:Objective to investigate the clinical significance of neurogranin (neurograinin,NG) as a marker of peripheral circulation in patients with acute craniocerebral injury (traumatic injury,TBI). Methods 71 patients with TBI were diagnosed by (CT) or magnetic resonance imaging (MRI) in Wuxi 101 Hospital. 85 patients with normal physical examination in Wuxi Hospital of traditional Chinese Medicine were used as normal control group. The level of NG in peripheral blood of TBI patients and normal control group was detected by ELISA double antibody sandwich method, and the prothrombin time (PT), fibrin (Fib), was detected by coagulation method. C-reactive protein (CRP), was detected by latex enhanced immunoturbidimetry. The number of platelet (PLT) was measured by automatic five-classification blood analyzer. Results the serum NG level of TBI patients was 850.51 (647.96962.11) pg/m / L, and that of normal control group was 612.44 (534.44733.9) pg/m / L. The serum NG level of TBI patients was significantly higher than that of normal control group (U 鈮，
本文编号：2488301
[Abstract]:Objective to investigate the clinical significance of neurogranin (neurograinin,NG) as a marker of peripheral circulation in patients with acute craniocerebral injury (traumatic injury,TBI). Methods 71 patients with TBI were diagnosed by (CT) or magnetic resonance imaging (MRI) in Wuxi 101 Hospital. 85 patients with normal physical examination in Wuxi Hospital of traditional Chinese Medicine were used as normal control group. The level of NG in peripheral blood of TBI patients and normal control group was detected by ELISA double antibody sandwich method, and the prothrombin time (PT), fibrin (Fib), was detected by coagulation method. C-reactive protein (CRP), was detected by latex enhanced immunoturbidimetry. The number of platelet (PLT) was measured by automatic five-classification blood analyzer. Results the serum NG level of TBI patients was 850.51 (647.96962.11) pg/m / L, and that of normal control group was 612.44 (534.44733.9) pg/m / L. The serum NG level of TBI patients was significantly higher than that of normal control group (U 鈮，
本文编号：2488301
本文链接：https://www.wllwen.com/yixuelunwen/waikelunwen/2488301.html
最近更新
教材专著
