舒筋活血片联合玻璃酸钠治疗膝关节骨性关节炎临床效果及对滑膜液炎症因子的影响

发布时间：2019-06-07 17:46

【摘要】：目的:分析舒筋活血片联合玻璃酸钠治疗膝关节骨性关节炎临床效果及对滑膜液炎症因子的影响。方法:以我院2014年11月~2016年10月收治的126例膝关节骨性关节炎患者为研究对象,随机原则分为对照组和治疗组,各63例。两组均接受玻璃酸钠注射治疗,观察组另给予舒筋活血片治疗,分析两组的疗效和炎症指标变化以及安全性。结果:(1)观察组总有效率为90.48%,明显高于对照组71.43%。治疗后,观察组Lysholm膝关节评分、WOMAC评分和关节VAS评分分别为(85.24±6.01、28.59±4.29、2.19±0.55)分,均优于对照组(73.29±5.53、40.25±4.58、3.16±0.65)分。(3)治疗后,观察组滑膜液炎症因子IL-6、TNF-ɑ和hs-CRP水平分别为(112.5±18.5pg/ml、0.45±0.08μg/ml、6.16±1.73μg/ml),均明显低于对照组(141.0±22.4pg/m、0.63±0.09μg/ml、8.39±1.82μg/ml)。(4)治疗期间,观察组不良反应比例为1.59%,低于对照组6.35%,但组间差异无统计学意义。结论:舒筋活血片可提高膝关节骨性关节炎治疗效果,减轻炎症和疼痛感。
[Abstract]:Objective: to analyze the clinical effect of Shujin Huoxue tablet combined with sodium hyaluronate in the treatment of knee osteoarthritis and its effect on inflammatory factors in synovial fluid. Methods: 126 patients with knee osteoarthritis treated in our hospital from November 2014 to October 2016 were randomly divided into control group (n = 63) and treatment group (n = 63). Both groups were treated with sodium hyaluronate injection, and the observation group was treated with Shujin Huoxue tablet. The curative effect, inflammatory index and safety of the two groups were analyzed. Results: (1) the total effective rate of the observation group was 90. 48%, which was significantly higher than that of the control group (71. 43%). After treatment, the knee joint score, WOMAC score and joint VAS score of the observation group were (85.24 卤6.01), 28.59 卤4.29 and 2.19 卤0.55, respectively, which were better than those of the control group (73.29 卤5.53, 40.25 卤4.58, 3.16 卤0.65). (3) after treatment, the knee joint score, the knee joint score and the joint VAS score of the observation group were (85.24 卤6.01), 28.59 卤4.29 and 2.19 卤0.55, respectively. The levels of inflammatory factors IL-6,TNF- and hs-CRP in synovial fluid in the observation group were (112.5 卤18.5 PG / ml), 0.45 卤0.08 渭 g / ml, 6.16 卤1.73 渭 g / ml), 141.0 卤22.4 mg / m and 0.63 卤0.09 渭 g / ml, respectively, which were significantly lower than those in the control group (0.63 卤0.09 渭 g / ml). 8.39 卤1.82 渭 g / ml). (4) during treatment, the proportion of adverse reactions in the observation group was 1.59%, which was lower than that in the control group (6.35%), but there was no significant difference between the two groups. Conclusion: Shujin Huoxue tablet can improve the therapeutic effect of knee osteoarthritis and reduce inflammation and pain.
【作者单位】： 新疆维吾尔自治区中医医院;
【分类号】：R684.3
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本文编号：2494977