血液灌流联合甲泼尼龙治疗蜂毒蛰伤导致的多脏器衰竭的疗效观察

发布时间：2019-06-14 19:00

【摘要】：目的研究血液灌流联合甲泼尼龙治疗蜂毒蛰伤致多脏器衰竭的临床效果。方法临床纳入80例我院2012年4月至2015年8月期间收治蜂毒蛰伤合并多脏器衰竭的患者,所有患者按入院顺序分为两组各40例。其中40例患者单纯采用血液灌流进行治疗作为对照组,另40例患者在血液灌流基础上联合甲泼尼龙冲击治疗作为观察组。观察两组患者肝肾功能及其它指标等。结果治疗前两组患者肝肾功能对比无差异,P0.05;治疗后观察组TBiL、ALT以及SCr水平均明显低于对照组,P0.05。治疗前两组患者生化指标对比无差异,P0.05;治疗后观察组CK、CK-MB、LDH、WBC水平均低于对照组,PLT、Hb水平均高于对照组,P0.05。结论血液灌流可有效缓解急性多脏器功能衰竭,联合甲泼尼龙治疗可改善功能受损器官的恢复,改善机体内环境指标的紊乱,维持患者酸碱、水电解质平衡,促进肝肾功能恢复,值得临床应用及推广。
[Abstract]:Objective to study the clinical effect of hemoperfusion combined with methylprednisolone in the treatment of multiple organ failure caused by bee poison stinging injury. Methods from April 2012 to August 2015, 80 patients with bee poison stinging injury complicated with multiple organ failure were treated in our hospital. All patients were divided into two groups according to the order of admission. Forty patients were treated with hemoperfusion as control group, and the other 40 patients were treated with methylprednisolone pulse therapy as observation group. The liver and kidney function and other indexes of the two groups were observed. Results there was no significant difference in liver and kidney function between the two groups before treatment (P0.05). After treatment, the levels of TBiL,ALT and SCr in the observation group were significantly lower than those in the control group (P0.05). There was no significant difference in biochemical indexes between the two groups before treatment, P0.05. after treatment, the level of CK,CK-MB,LDH,WBC in the observation group was lower than that in the control group, and the level of PLT,Hb in the observation group was higher than that in the control group (P0.05). Conclusion Hemoperfusion can effectively alleviate acute multiple organ failure. Combined with methylprednisolone can improve the recovery of damaged organs, improve the disorder of internal environmental indexes, maintain the balance of acid and alkali, water and electrolyte, and promote the recovery of liver and kidney function. It is worthy of clinical application and promotion.
【作者单位】：郑州大学附属洛阳市中心医院肾病内科;
【分类号】：R646;R459.7

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