纳米炭混悬液与美蓝在乳腺癌前哨淋巴结活检中的应用研究

发布时间：2019-08-12 09:14

【摘要】：目的探讨纳米炭混悬液与美蓝在乳腺癌前哨淋巴结活检中的应用价值和优势。方法收集303例临床腋窝淋巴结阴性且进行了前哨淋巴结活检手术的早中期乳腺癌病例,依据使用纳米炭混悬液或者美蓝作为淋巴结示踪剂分为两组,其中纳米炭组138例,美蓝组165例。手术切除的前哨淋巴结送病理检查。结果纳米炭组检出率为99.3%,美蓝组检出率为93.9%,使用纳米炭混悬液SLN检出率高于使用美蓝者(P0.05)。纳米炭组共检出SLN 696枚,平均5.1枚,美蓝组检出SLN 544枚,平均3.5枚(P=0.000),使用纳米炭混悬液检出的SLN比美蓝要多。使用美蓝时,出现示踪不理想的概率高于纳米炭(P0.05)。使用上述两种示踪剂的检出率与患者肿瘤大小、肿瘤部位、术前腋窝淋巴结触诊情况、肿瘤分子分型、年龄、肥胖因素均无关(P均0.05)。结论纳米炭混悬液示踪效果好,能检出更多的SLN,SLN检出率更高。
[Abstract]:Objective to investigate the value and advantages of nano-carbon suspension and methylene blue in sentinel lymph node biopsy of breast cancer. Methods 303 cases of breast cancer with negative axillary lymph nodes and sentinel lymph node biopsies were divided into two groups according to the use of nano-carbon suspension or methylene blue as lymph node tracer, including 138 cases in nano-carbon group and 165 cases in methylene blue group. Surgical resection of sentinel lymph nodes was sent for pathological examination. Results the detection rate of SLN in nano-carbon group was 99.3%, and that in methylene blue group was 93.9%. The detection rate of DNA in nano-carbon suspension was higher than that in methylene blue group (P 0.05). A total of 696 SLN were detected in the nano-carbon group, with an average of 5.1 in the methylene blue group, and 544 SLN in the methylene blue group (P 鈮，

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