肩袖修复重建的系列基础研究
发布时间：2021-02-23 01:36
目的肩袖损伤是肩部最常见的病变之一,常需要手术治疗。近年来,虽然肩袖修补术有着长足进步,术后的再撕裂率和并发症的发生率仍然相当高[1,2],肩袖与骨的愈合能力较差是造成术后再撕裂率偏高的主要原因。肩袖损伤后,腱-骨止点的结构破坏,修补后的肌腱与骨的愈合只能形成纤维疤痕组织,从而容易再次损伤[3,4]。本实验为了探究腱-骨愈合与力学刺激、内环境和生物材料的关系,设计了一系列针对肩袖损伤修补及重建的基础性研究。将原位肩袖组织进行穿骨隧道固定,探究隧道内植入式肩袖修复方式中肌腱在骨隧道中的腱-骨愈合情况;并且利用双极电纺纤维膜在腱-骨愈合处诱导腱-骨愈合中胶原纤维增生和骨长入,了解双极纳米纤维膜在肌腱与骨的愈合中的作用;在巨大肩袖损伤的治疗中,利用自体肌腱桥接巨大肩袖损伤中肌腱与骨的缺损,与补片桥接法做对比,评估自体肌腱桥接修复治疗巨大肩袖损伤的临床可行性,通过观察移植肌腱在骨隧道中的重塑,综合了解肩袖修补和重建中的腱-骨愈合情况,寻找促进愈合的手术方式及新型生物材料方法加强腱-骨愈合的微结构再生。方法1.取新西兰白兔建立肩袖损伤模型,在足印区建立...
【文章来源】：上海交通大学上海市 211工程院校 985工程院校 教育部直属院校
【文章页数】：111 页
【学位级别】：博士
【部分图文】：
图1.双极纳米纤维膜应用于肩袖损伤修补的示意图
图 2 Into-tunnel repair 手术过程。(a)完整的冈上肌止点。（b）纵行劈开冈上肌肌腱残端术。（c）分离编织后的冈上肌肌腱。（d）分离后的肌腱拉入骨隧道中Fig. 2. Repair procedures of the torn supraspinatus tendon (SSP) to the greater tuberosity(GT) in an into-tunnel manner. (a) Intact tendon-bone complex (b) Rotator cuff tear model wascreated and SSP split in half. (c) The split ends were sutured and two parallel bone tunnels werecreated from the decorticated site to the lateral aspect of greater tuberosity. (d) Each suturedtendon is inserted into the bone tunnel on GT and the attached suture firmly tied to the lateralaspect of the humeral cortex.
图 2 Into-tunnel repair 手术过程。(a)完整的冈上肌止点。（b）纵行劈开冈上肌端术。（c）分离编织后的冈上肌肌腱。（d）分离后的肌腱拉入骨隧道中Fig. 2. Repair procedures of the torn supraspinatus tendon (SSP) to the greater tube(GT) in an into-tunnel manner. (a) Intact tendon-bone complex (b) Rotator cuff tear modecreated and SSP split in half. (c) The split ends were sutured and two parallel bone tunnelcreated from the decorticated site to the lateral aspect of greater tuberosity. (d) Each suttendon is inserted into the bone tunnel on GT and the attached suture firmly tied to the laaspect of the humeral cortex.
本文编号：3046826
【文章来源】：上海交通大学上海市 211工程院校 985工程院校 教育部直属院校
【文章页数】：111 页
【学位级别】：博士
【部分图文】：
图1.双极纳米纤维膜应用于肩袖损伤修补的示意图
图 2 Into-tunnel repair 手术过程。(a)完整的冈上肌止点。（b）纵行劈开冈上肌肌腱残端术。（c）分离编织后的冈上肌肌腱。（d）分离后的肌腱拉入骨隧道中Fig. 2. Repair procedures of the torn supraspinatus tendon (SSP) to the greater tuberosity(GT) in an into-tunnel manner. (a) Intact tendon-bone complex (b) Rotator cuff tear model wascreated and SSP split in half. (c) The split ends were sutured and two parallel bone tunnels werecreated from the decorticated site to the lateral aspect of greater tuberosity. (d) Each suturedtendon is inserted into the bone tunnel on GT and the attached suture firmly tied to the lateralaspect of the humeral cortex.
图 2 Into-tunnel repair 手术过程。(a)完整的冈上肌止点。（b）纵行劈开冈上肌端术。（c）分离编织后的冈上肌肌腱。（d）分离后的肌腱拉入骨隧道中Fig. 2. Repair procedures of the torn supraspinatus tendon (SSP) to the greater tube(GT) in an into-tunnel manner. (a) Intact tendon-bone complex (b) Rotator cuff tear modecreated and SSP split in half. (c) The split ends were sutured and two parallel bone tunnelcreated from the decorticated site to the lateral aspect of greater tuberosity. (d) Each suttendon is inserted into the bone tunnel on GT and the attached suture firmly tied to the laaspect of the humeral cortex.
本文编号：3046826
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