Propofol protects against blood-spinal cord barrier disrupti

发布时间：2022-02-10 05:36

　　Propofol has been shown to exert neuroprotective effects on the injured spinal cord.However,the effect of propofol on the blood-spinal cord barrier（BSCB） after ischemia/reperfusion injury（IRI） is poorly understood.Therefore,we investigated whether propofol could maintain the integrity of the BSCB.Spinal cord IRI（SCIRI） was induced in rabbits by infrarenal aortic occlusion for 30 minutes.Propofol,30 mg/kg,was intravenously infused 10 minutes before aortic clamping as well as at the onset of reper... 

【文章来源】：Neural Regeneration Research. 2017,12(01)SCICSCD

【文章页数】：8 页

【文章目录】：
Graphical Abstract
Introduction
Materials and Methods
    Animals
    Establishment of SCIRI model
    Propofol intervention
    Neurological assessment
    Histological observation
    Measurement of BSCB permeability
    Real-time PCR
    Western blot assay
    Statistical analysis
Results
    Propofol improved neurological function after SCIRI
    Propofol improved the morphology of the spinal cord after I/R
    Propofol decreased BSCB permeability after IRI
    Propofol inhibited the expression of NK-κB(p65)in the I/R-injured spinal cord
    Propofol inhibited the upregulation of MMP-9 after SCIRI
    Propofol suppressed the reduction in occludin and claudin-5 expression in the I/R-injured spinal cord
Discussion



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