扫频光学相干断层扫描在眼科的应用进展

发布时间：2018-07-31 16:40

【摘要】：精准定性、定量评估眼前节及后节的影像学技术,不仅对多种眼病的准确诊断至关重要,同时也可为治疗方案、手术方式以及随访提供重要参考依据。作为一种分辨率高、非接触无创的成像技术,光学相干断层扫描(optical coherence tomography,OCT)已成为玻璃体视网膜相关疾病必不可少的辅助检查工具。近几年提出的扫频光学相干断层扫描成像(swept-source OCT,SS-OCT)技术,具备扫描速度提高及穿透深度加深的优点,同时运用不同成像系统可获得眼部不同层次结构精准的成像。新型的SS-OCT成像技术可用于评估眼前节结构,如角膜移植术后角膜瓣、前房参数等检查,也加深了对玻璃体视网膜相关疾病如糖尿病性黄斑病变、眼底新生血管的转归和黄斑毛细血管扩张等疾病病理形态改变的认识。同时,运用玻璃体增强成像(enhanced vitreous visualization,EVV)、分层扫描(En face SS-OCT)和SS-OCT血管造影等成像系统,可为眼底相关疾病,如玻璃体后脱离、视网膜前膜、视网膜脱离、糖尿病牵拉性视网膜脱离等手术适应证制定最佳的治疗方案并协助术后随访。此外,该技术还为多种眼部疾病如青光眼、眼肿瘤的病理形态学观察提供精准的微结构成像图。本文主要对SS-OCT的技术原理及临床应用进展等方面进行综述。
[Abstract]:Accurate qualitative and quantitative evaluation of the imaging techniques of anterior segment and posterior segment is not only very important for the accurate diagnosis of various eye diseases, but also provides an important reference for the treatment, operation and follow-up. As a high-resolution, non-contact non-invasive imaging technique, optical coherence tomography (Oct) has become an indispensable auxiliary examination tool for vitreoretinal diseases. In recent years, swept-source optical coherence tomography (SS-OCT) has the advantages of increasing scanning speed and deepening penetration depth. At the same time, different imaging systems can be used to obtain accurate imaging of different ocular layers. New SS-OCT imaging techniques can be used to evaluate the structure of anterior segment, such as corneal flap after corneal transplantation, parameters of anterior chamber and so on. It also deepens vitreoretinal diseases such as diabetic macular disease. Recognition of fundus neovascularization and macular capillary dilatation. At the same time, imaging systems such as vitreous enhancement imaging (enhanced vitreous visualization (EVV), layered scanning (En face SS-OCT) and SS-OCT angiography can be used as fundus related diseases, such as posterior vitreous detachment, preretinal membrane, retinal detachment, and so on. The optimal treatment for diabetic traction retinal detachment and other surgical indications was established and postoperative follow-up was assisted. In addition, the technique provides accurate microstructural imaging for various ocular diseases such as glaucoma and pathomorphology of eye tumors. This article reviews the technical principle and clinical application of SS-OCT.
【作者单位】：南华大学附属第一医院眼科;南昌大学第一附属医院眼科;
【基金】：国家自然科学基金资助(编号81660158、81160118、81160148、81460092、81400372) 江西省远航工程(编号:2014022) 江西省自然科学基金重大项目(编号:2016ACB21017) 江西省自然科学青年基金(编号:20151BAB215016) 江西省科技支撑计划项目(编号:20151BBG70223) 江西省卫计委科技计划面上项目(编号:20175116、20155204)~~
【分类号】：R770.4

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