中性粒细胞与淋巴细胞比值在鼻咽癌的临床意义初探
发布时间：2018-08-17 19:47
【摘要】：目的：在大多数恶性肿瘤当中，升高的中性粒细胞/淋巴细胞比值（Neutrophil-to-LymphocyteRatio，NLR）提示肿瘤的不良预后，研究显示，高中性粒细胞/淋巴细胞比值与胃癌、肝癌、肺癌、结肠癌、胰腺癌等肿瘤患者的死亡率密切相关。然而，中性粒细胞/淋巴细胞比值与鼻咽癌预后的关系仍然不是十分清楚，就此本文对中性粒细胞/淋巴细胞比值在鼻咽癌预后的临床意义进行探讨。 方法：回顾性分析2001年1月至2010年1月我院116例鼻咽癌患者（男76例，女40例）,记录年龄、性别、白细胞计数（WBC）、中性粒细胞计数（N）、淋巴细胞计数（L），并计算出中性粒细胞/淋巴细胞比值（NLR），比较116例患者中复发与未复发者年龄、性别、中性粒细胞计数（N）、淋巴细胞计数（L），NLR,分析比较年龄、性别、N、L、NRL对鼻咽癌患者预后的影响。 结果：复发组NLR明显高于未复发组(P0.001)，复发组L低于未复发组（P0.05）。通过ROC曲线，NLR3.69时，其中未复发与复发比例：79.41%，，20.59%，NLR≥3.69时，未复发与复发比例：20.83%，79.17%。差异具有统计学意义（P0.001）。复发组性别与未复发组无明显统计学差异（P0.05） 结论：NLR是一种新的炎症指标，NLR对鼻咽癌的预后复发有一定的预测价值，有望作为预测鼻咽癌预后的一种简单方便的生物指标运用于临床工作中，值得临床工作者的重视。
[Abstract]:Objective: in most malignant tumors, the increased Neutrophil-to-LymphocyteRatiolymphocyte ratio (NLR) indicates the poor prognosis of the tumor. Studies have shown that high neutrophil / lymphocyte ratio is associated with gastric cancer, liver cancer, lung cancer and colon cancer. The mortality of pancreatic cancer and other cancer patients is closely related. However, the relationship between the neutrophil / lymphocyte ratio and the prognosis of nasopharyngeal carcinoma is not very clear. In this paper, the clinical significance of neutrophil / lymphocyte ratio in the prognosis of nasopharyngeal carcinoma is discussed. Methods: from January 2001 to January 2010, 116 patients with nasopharyngeal carcinoma (76 males and 40 females) in our hospital were analyzed retrospectively. Leukocyte count (WBC), neutrophil count (N), lymphocyte count (L), and neutrophil / lymphocyte ratio (NLR), were calculated to compare the age and sex of recurrent and non-recurrent patients. Neutrophil count (N), lymphocyte count (L) / NLR) was used to analyze the influence of age and sex on the prognosis of nasopharyngeal carcinoma (NPC) patients. Results: the NLR of recurrent group was significantly higher than that of non-recurrent group (P0. 001), and the L of recurrent group was lower than that of non-recurrent group (P0.05). Through the ROC curve NLR 3.69, the ratio of no recurrence to recurrence was: 79.41% and 20.59NLR 鈮
本文编号：2188711
[Abstract]:Objective: in most malignant tumors, the increased Neutrophil-to-LymphocyteRatiolymphocyte ratio (NLR) indicates the poor prognosis of the tumor. Studies have shown that high neutrophil / lymphocyte ratio is associated with gastric cancer, liver cancer, lung cancer and colon cancer. The mortality of pancreatic cancer and other cancer patients is closely related. However, the relationship between the neutrophil / lymphocyte ratio and the prognosis of nasopharyngeal carcinoma is not very clear. In this paper, the clinical significance of neutrophil / lymphocyte ratio in the prognosis of nasopharyngeal carcinoma is discussed. Methods: from January 2001 to January 2010, 116 patients with nasopharyngeal carcinoma (76 males and 40 females) in our hospital were analyzed retrospectively. Leukocyte count (WBC), neutrophil count (N), lymphocyte count (L), and neutrophil / lymphocyte ratio (NLR), were calculated to compare the age and sex of recurrent and non-recurrent patients. Neutrophil count (N), lymphocyte count (L) / NLR) was used to analyze the influence of age and sex on the prognosis of nasopharyngeal carcinoma (NPC) patients. Results: the NLR of recurrent group was significantly higher than that of non-recurrent group (P0. 001), and the L of recurrent group was lower than that of non-recurrent group (P0.05). Through the ROC curve NLR 3.69, the ratio of no recurrence to recurrence was: 79.41% and 20.59NLR 鈮
本文编号：2188711
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