阻塞性睡眠呼吸暂停综合征血浆白介素-18和单核细胞趋化蛋白-1水平的观察及其临床意义

发布时间：2018-11-08 14:03

【摘要】：目的：通过研究阻塞性睡眠呼吸暂停综合征(Obstructive Sleep Apnea Syndrome, OSAS)患者血清中白介素-18(IL-18)和单核细胞趋化蛋白-1(MCP-1)水平变化,探讨IL-18和MCP-1在OSAS中的作用。方法：选择来我院就诊的56例OSAS患者和25例健康人,分别作为实验组和对照组。分别测定实验组患者术前、术后和对照组的血清中IL-18和MCP-1的水平及其他一般情况(睡眠呼吸暂停低通气指数、最低动脉血氧饱和度、收缩压、舒张压、脉压差)的变化。结果：(1)OSAS患者的脉压差明显高于对照组,且随着OSAS的患病程度加重脉压差逐渐增高；OSAS患者脉压差的增高与IL-18和MCP-1水平增高密切相关。(2)OSAS患者血清中IL-18和MCP-1的水平远远高于健康人,且OSAS的患病严重程度与IL-18和MCP-1水平密切相关,同时IL-18和MCP-1之间存在线性关系；(3)OSAS患者经过手术治疗后血清中IL-18和MCP-1含量较术前明显下降。结论：(1)OSAS患者得心血管疾病的风险明显高于正常人,且随着OSAS病情的严重程度,患心血管疾病的风险越大,其机制可能与血清中IL-18和MCP-1水平的增高密切相关。(2)血清中IL-18和MCP-1的水平与OSAS的发病密切相关,并且直接反应了OSAS病情的严重程度。
[Abstract]:Objective: to study the changes of serum levels of interleukin-18 (IL-18) and monocyte chemoattractant protein-1 (MCP-1) in patients with obstructive sleep apnea syndrome (Obstructive Sleep Apnea Syndrome, OSAS). To explore the role of IL-18 and MCP-1 in OSAS. Methods: 56 patients with OSAS and 25 healthy persons were selected as experimental group and control group. The serum levels of IL-18 and MCP-1 were measured before, after operation and in the control group (sleep apnea hypopnea index, minimum arterial oxygen saturation, systolic blood pressure, diastolic blood pressure), and other general conditions (sleep apnea hypopnea index, minimum arterial oxygen saturation, systolic blood pressure, diastolic blood pressure). Pulse pressure difference). Results: (1) the pulse pressure difference of OSAS patients was significantly higher than that of the control group, and gradually increased with the severity of OSAS. The increase of pulse pressure difference in OSAS patients was closely related to the increase of IL-18 and MCP-1 levels. (2) the levels of IL-18 and MCP-1 in the serum of OSAS patients were much higher than those of healthy people, and the severity of OSAS was closely related to the levels of IL-18 and MCP-1. At the same time, there is a linear relationship between IL-18 and MCP-1. (3) the levels of IL-18 and MCP-1 in serum of OSAS patients were significantly lower than those before operation. Conclusion: (1) the risk of cardiovascular disease in OSAS patients is significantly higher than that in normal controls, and the risk of cardiovascular disease increases with the severity of OSAS. The mechanism may be closely related to the increase of IL-18 and MCP-1 in serum. (2) the levels of IL-18 and MCP-1 in serum are closely related to the pathogenesis of OSAS and directly reflect the severity of OSAS.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R766

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