血小板—中性粒细胞聚集体在急性ST段抬高型心肌梗死患者中表达的研究

发布时间：2018-01-26 15:11

  本文关键词： 心肌梗死 血小板聚集 血小板—中性粒细胞聚集体　出处：《中国循环杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的:本文探讨血小板—中性粒细胞聚集体(PNA)在急性ST段抬高型心肌梗死(STEMI)患者中的表达。方法:共计纳入于我院心内科住院的STEMI患者40例为STEMI组,同期收集健康查体者30例为对照组。于入院即刻抽取静脉血,应用流式细胞仪分别检测PNA、血小板—单核细胞聚集体(PMA)和血小板—淋巴细胞聚集体(PlyA)表达水平。比较两组PNA、PMA和PlyA表达水平的差异。结果:与对照组相比,STEMI组PlyA(P=0.245)和PMA(P=0.312)水平升高,但差异无统计学意义。STEMI组PNA水平明显高于对照组(P0.05),差异具有统计学意义。相关性分析表明,血小板-白细胞聚集体(PLA)水平与肌酸激酶同工酶(r=0.4992,P0.01)和肌钙蛋白Ⅰ(r=0.4365,P0.01)呈正相关。结论:本研究表明,在STEMI患者中PLA尤其是PNA水平明显增高,提示高水平的PNA可以作为急性心肌梗死的一个新指标。
[Abstract]:Objective: to investigate the role of platelet-neutrophil aggregates (PNAs) in acute ST-segment elevation myocardial infarction (STEMI). Methods: a total of 40 patients with STEMI included in our department of cardiology were included in the STEMI group. 30 healthy controls were collected at the same time. Venous blood was collected immediately after admission and PNA was detected by flow cytometry. The expression levels of platelet-monocyte aggregates (PMA) and platelet-lymphocyte aggregates (Plya A) were compared between the two groups. Results: compared with the control group, the expression levels of PMA and PlyA were increased. But the difference was not statistically significant. The PNA level in STEMI group was significantly higher than that in control group (P0.05), the difference was statistically significant. The levels of PLA and creatine kinase isoenzyme rnr 0.4992P0.01) and cardiac troponin 鈪，

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