缬沙坦联合氨氯地平治疗冠心病合并高血压临床观察

发布时间：2018-01-26 16:21

本文关键词： 缬沙坦氨氯地平缬沙坦联合氨氯地平冠心病高血压　出处：《吉林大学》2015年硕士论文　论文类型：学位论文

【摘要】：研究目的：通过评估临床对冠心病合并高血压患者应用缬沙坦联合氨氯地平治疗的临床疗效及可行性。研究方法：将2013年5月-2014年5月来我院就诊治疗的诊断明确的冠心病合并高血压患者纳入研究，随机平行将患者等分成2组（每组34人），对照组给予硝苯地平缓释片用药，观察组实施缬沙坦配合氨氯地平治疗，研究2组的治疗结局。确诊后，对本实验患者提供测量血压、补液及对症处理等常规治疗，同时根据用药方案，对2组患者进行如下施治。对照组（硝苯地平缓释片方案）：每次剂量10mg，每日口服2次，此后根据患者的血压值将每日剂量调整至40mg，待血压值降至正常水平时再改成20mg/d维持，疗程共4周。观察组（缬沙坦＋氨氯地平方案）：缬沙坦、氨氯地平每次剂量各为80mg和5mg，每日清晨口服1次，疗程与对照组相同。研究结果：治疗后，观察组的心绞痛疗效是94.1%，要显著性高于对照组的73.5%，有统计学意义（P＜0.05）。治疗前，2组的收缩压与舒张压对比相仿（P＞0.05），经治疗后均出现改善，且观察组相比对照组改善更显著（P＜0.05）。2组用药期间均有不适出现，其中观察组发生率是2.9%，，要相比对照组的17.6%更低（P＜0.05）。结论： 1.缬沙坦、氨氯地平，每次剂量各为80mg和5mg，每日清晨口服1次，较硝苯地平缓释片，每次剂量10mg，每日口服2次，更早改善心绞痛症状。 2.缬沙坦、氨氯地平，每次剂量各为80mg和5mg降压效果更优于硝苯地平缓释片，每次剂量10mg。 3.缬沙坦、氨氯地平，每次剂量各为80mg和5mg患者耐受性良好，对心率及肝功、生化等指标影响较小，适于临床推广。
[Abstract]:Objectives of the study: To evaluate the clinical efficacy and feasibility of valsartan combined with amlodipine in patients with coronary heart disease and hypertension. Research methods: From May 2013 to May 2014, the patients with coronary heart disease (CHD) complicated with hypertension were divided into two groups (34 patients in each group). The control group was treated with nifedipine sustained release tablets, the observation group was treated with valsartan combined with amlodipine, and the treatment outcome of the two groups was studied. After diagnosis, the patients were given routine treatment such as blood pressure measurement, fluid resuscitation and symptomatic treatment. According to the medication scheme, the two groups were treated as follows. Control group (nifedipine sustained-release tablet regimen: 10mg per dose, twice a day, then adjusted to 40mg daily according to the patient's blood pressure. When blood pressure dropped to normal level, it was maintained at 20 mg / d for 4 weeks. The observation group (valsartan + amlodipine regimen: valsartan, amlodipine 80 mg and 5 mg each time, oral once a day, the course of treatment was the same as the control group. Results of the study: After treatment, the effect of angina pectoris in the observation group was 94.1%, which was significantly higher than that in the control group (73.5%, P < 0.05). Systolic blood pressure and diastolic blood pressure in both groups were similar to those in the control group (P > 0.05), and were improved after treatment, and there was discomfort in the observation group compared with the control group (P < 0.05). The incidence of the observation group was 2.9, which was lower than that of the control group (17.6%, P < 0.05). Conclusion: 1. Valsartan, amlodipine, 80 mg and 5 mg each time, orally once a day, than nifedipine sustained release tablets, 10 mg per dose, 2 times a day. Improve angina symptoms earlier. 2. The antihypertensive effect of valsartan and amlodipine was better than that of nifedipine sustained-release tablets at the dose of 80 mg and 5 mg, respectively, with a dose of 10 mg / time. 3. Valsartan, amlodipine, each dose of 80mg and 5mg patients had good tolerance, had little effect on heart rate, liver function, biochemistry and so on, and was suitable for clinical popularization.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R544.1;R541.4

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