冷冻球囊消融对比射频消融在房颤消融治疗中有效性和安全性的荟萃分析

发布时间：2018-01-29 03:29

本文关键词： 房颤冷冻球囊消融射频消融荟萃分析　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:目前冷冻球囊消融和射频消融是用于房颤导管消融的两种不同方法;然而,关于哪种消融方法更好并没有统一共识。因此我们尝试针对已发表的随机对照临床试验进行荟萃分析比较冷冻消融与射频消融的有效性和安全性,从而为临床合理治疗提供循证学依据。方法:在PubMed,EMBASE,CNKI和万方数据库检索截止2016年5月发表的对比冷冻球囊消融和射频消融用于房颤患者消融治疗的随机对照研究,筛选目的试验进行相关文献的质量评价,提取所需要的实验数据,并使用RevMan软件5.3版本对研究数据进行分析,比较两种消融方式治疗房颤的复发率、并发症发生率、手术时间及曝光时间等相关数据并对这些数据进行荟萃分析。结果:最终纳入6项研究,所有的临床试验都是在2012年至2016年之间发表的,纳入的6项研究均为随机对照试验;共包括642名接受了冷冻球囊消融治疗的患者,651名接受了射频消融治疗的患者。荟萃分析结果提示:和射频消融相比,使用冷冻球囊消融的患者,其有效性(房颤复发率)无明显差异(I2=0%,P=0.57);冷冻球囊消融组的并发症多于射频消融(I2=0%,P=0.005);但冷冻球囊消融组的手术总时长较射频消融组显著缩短(I2=31%,P0.05)。结论:和射频消融相比,冷冻球囊消融其有效性无明显差异,但冷冻球囊消融组的手术总时长较射频消融组减少,然而冷冻球囊消融组的并发症却多于射频消融,关于两种消融方法的安全性和有效性的对比还需要一些大型的临床研究进一步证实。
[Abstract]:Objective: cryoballoon ablation and radiofrequency ablation is currently used two different methods for catheter ablation of atrial fibrillation; however, about what kind of better ablation method and there is no uniform consensus. So we try to freeze a meta-analysis was performed to compare the efficacy and safety of ablation and radiofrequency ablation for randomized controlled clinical trials have been published, so as to provide evidence-based basis for clinical treatment. Methods: PubMed, EMBASE, CNKI and Wanfang database published by the end of May 2016 comparing cryoballoon ablation and radiofrequency ablation for patients with atrial fibrillation ablation with treatment of the quality evaluation to select the test of related literature, experimental data to be extracted, and 5.3 the version of the research data for analysis using RevMan software, comparison of two kinds of ablation treatment of atrial fibrillation recurrence rate, complication rate, operation time and exposure time. The relevant data and perform a meta-analysis of these data. Results: a total of 6 studies, all clinical trials are published between 2012 to 2016, 6 included studies were randomized controlled trials; including a total of 642 patients received cryoballoon ablation therapy, 651 patients received radiofrequency ablation therapy a meta-analysis of patients. Results: radiofrequency catheter ablation and compared using cryoballoon ablation patients, its effectiveness (the recurrence rate of atrial fibrillation) had no significant difference (I2=0%, P=0.57); cryoballoon ablation group had more complications than radiofrequency ablation (I2=0%, P=0.005); but the cryoballoon ablation group of surgery, the total length of a radio frequency the ablation group was significantly shortened (I2=31%, P0.05). Conclusion: radiofrequency catheter ablation and compared the effectiveness of cryoballoon ablation has no obvious difference, but the cryoballoon ablation group operation is the total length of the ablation group decreased, however cryoballoon ablation The complication of the group is more than the radiofrequency ablation. The comparison of the safety and effectiveness of the two ablation methods is further confirmed by a number of large clinical studies.

【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.75

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