MHR水平对冠状动脉慢血流发病的预测价值

发布时间：2018-01-29 07:48

本文关键词： 冠状动脉慢血流单核细胞数与高密度脂蛋白胆固醇比值混杂因素　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨血浆单核细胞数与高密度脂蛋白胆固醇比值(MHR)水平对冠状动脉慢血流(SCF)发病的预测价值。方法:选择2014年1月-2016年12月在我院心脏中心行冠状动脉造影检查显示有慢血流现象但冠状动脉未发现狭窄的患者457例(病例组),与同期因胸痛等不适就诊,经冠状动脉造影检查均未发现冠状动脉狭窄,冠状动脉无慢血流者503例(对照组)。检测两组外周血细胞计数及分类、空腹血糖、血脂、肝肾功能,并计算体重指数(body mass index BMI),MHR,血小板和淋巴结细胞比率(PLR),通过绘制ROC曲线判断MHR预测SCF发病的临界值,以临界值为切点分组,分为低MHR组,高MHR,比较两组临床资料的差别,并行多元Logistic回归分析SCF发病的危险因素。结果:病例组与对照组比较,年龄、体重、脉搏、平均血小板体积、肌酐、空腹血糖、甘油三酯、MHR、BMI两组间差异均有统计学意义(P0.05);绘制ROC曲线获得MHR切点为0.29,ROC曲线下的面积(AUC)0.561,P=0.001。多元Logistic回归分析显示年龄、男性、吸烟、高血压、糖尿病、尿酸、MHR均是SCF的危险因素,高MHR组发生SCF的风险是低MHR组的1.69倍,MHR(OR=1.69,CI 95%1.20-2.38,P0.01)。结论:MHR是SCF发病的独立危险因素,MHR水平对SCF的发病有预测价值,随MHR水平的增高,显著增加SCF的发病风险。
[Abstract]:Objective: to investigate the effect of plasma monocyte number and high density lipoprotein cholesterol ratio (MHRs) on coronary slow flow (SCF). Predictive value of morbidity. Methods:. Select 457 patients who underwent coronary angiography from January 2014 to December 2016 in the heart center of our hospital, which showed slow flow but no stenosis of coronary artery (. Case group). At the same time due to chest pain and other discomfort, no coronary artery stenosis was found by coronary angiography, and no slow flow of coronary artery was found in 503 cases (control group). Peripheral blood cell count and classification were detected in both groups. Fasting blood glucose, blood lipid, liver and kidney function, body mass index (BMI) and platelet and lymph node cell ratio (PLR) were calculated. The critical value of MHR for predicting the onset of SCF was determined by drawing ROC curve. The critical value was divided into two groups: low MHR group and high MHR group. The difference of clinical data between the two groups was compared. Results: age, body weight, pulse, mean platelet volume, creatinine, fasting blood glucose and triglyceride were compared between the case group and the control group. There was significant difference in MHRBMI between the two groups (P 0.05). ROC curve was drawn to obtain the area under the MHR cut point of 0.29 ROC curve. Multiple Logistic regression analysis showed that age was male. Smoking, hypertension, diabetes and uric acid were all risk factors of SCF. The risk of developing SCF in high MHR group was 1.69 times higher than that in low MHR group. ConclusionMHR is an independent risk factor for the pathogenesis of SCF. The level of MHR has predictive value in the pathogenesis of SCF. With the increase of MHR level, the risk of SCF increased significantly.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R543.3

【参考文献】