稳定型心绞痛患者经皮冠状动脉介入治疗后血浆OX40L水平与预后的关系

发布时间：2018-02-01 02:54

本文关键词： OXL 稳定型心绞痛经皮冠状动脉介入治疗预后　出处：《中国医科大学学报》2017年07期 　论文类型：期刊论文

【摘要】：目的观察稳定型心绞痛患者经皮冠状动脉介入治疗(PCI)术后血浆OX40L水平的变化趋势,并探讨其与患者预后的关系。方法选取稳定型心绞痛患者200例,均行PCI,测定术前及术后不同时间点血浆OX40L的浓度,观察血浆OX40L浓度的变化趋势。对所有患者进行18个月的随访,随访终点为不良心血管事件。结果患者PCI术后血浆OX40L浓度较术前明显升高(P0.05),术后24 h达峰值。185例患者随访成功,其中发生不良心血管事件(事件组)患者39例(21.08%),无心血管事件(无事件组)患者146例(78.92%)。事件组血浆OX40L峰值水平高于无事件组[分别为(37.51±6.17)和(30.95±3.81)pg/m L],差异有统计学意义(P0.05)。logistic回归分析显示,OX40L峰值与患者随访期间发生不良心血管事件密切相关(P0.05)。结论PCI术增加稳定型心绞痛患者OX40L的表达,峰值水平对术后18个月不良心血管事件有良好预测价值。
[Abstract]:Objective to observe the change trend of plasma OX40L level in patients with stable angina pectoris after percutaneous coronary intervention (PCI). Methods 200 patients with stable angina pectoris were selected and their plasma OX40L levels were measured before and after operation. The change trend of plasma OX40L concentration was observed. All patients were followed up for 18 months. Results the plasma OX40L concentration in patients with PCI was significantly higher than that before operation (P 0.05), and the peak value at 24 hours after operation was .185 cases were followed up successfully. There were 39 patients with adverse cardiovascular events (event group). The peak level of plasma OX40L in the event group was higher than that in the no event group. [It was 37.51 卤6.17) and 30.95 卤3.81g / mL, respectively. The difference was statistically significant (P 0.05). Logistic regression analysis showed. The peak value of OX40L was closely related to adverse cardiovascular events during follow-up. Conclusion PCI can increase the expression of OX40L in patients with stable angina pectoris. Peak level is a good predictor of adverse cardiovascular events 18 months after operation.
【作者单位】：沈阳医学院附属第二医院心内科;
【基金】：沈阳市科技计划(F13-220-9-39/F14-158-9-26) 沈阳医学院青年基金(20122037)
【分类号】：R541.4
【正文快照】： 经皮冠状动脉介入治疗(percutaneous coronaryintervention,PCI)目前是冠心病患者治疗的重要措施之一,能显著改善预后。但术后支架内再狭窄、支架内血栓形成、缺血事件再发等仍时有发生,这与PCI术加重局部炎症反应、介导心肌及血管损伤密切相关。研究[1]表明,OX40及其配体(OX4

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