骨髓腔内棕色脂肪细胞增生2例临床病理分析

发布时间：2018-02-02 07:50

  本文关键词： 骨髓腔 棕色脂肪细胞 白色脂肪细胞 免疫组织化学　出处：《临床与实验病理学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的探讨骨髓腔内棕色脂肪细胞增生性病变的临床病理学特征。方法回顾性分析2例骨髓腔内棕色脂肪细胞增生临床和影像学资料、病理组织学形态、免疫表型及随访资料。结果 2例患者年龄分别为64岁和49岁,男女各1例,例1伴椎间盘突出,病变位于L4椎体和椎弓根处;例2无明显不适,病变位于左胫骨中段。CT示均为髓腔内边界不清、密度不均的高密度影,骨皮质未见侵犯。组织学上髓腔内见圆形或多边形细胞散在或成簇分布于成熟脂肪组织内,胞质丰富,内含多个小脂滴,间质内富含薄壁血管,髓腔内骨小梁未见异常。免疫表型:多空泡细胞UCP1、S-100均呈阳性,CKpan、CD68、Calcitonin、PRLR均呈阴性。随访1年,患者均无复发。结论棕色脂肪细胞增生在骨髓腔内报道较少,肿瘤患者术后行18F-FDG PET/CT扫描复查时需注意与棕色脂肪组织鉴别。
[Abstract]:Objective to investigate the clinicopathological features of brown adipocyte hyperplasia in medullary cavity. Methods the clinical and imaging data and histopathological features of 2 cases of brown adipocyte hyperplasia in medullary cavity were analyzed retrospectively. Results the age of the two patients was 64 years old and 49 years old, male and female were 1 case, case 1 with disc herniation, the lesion was located at L4 vertebral body and pedicle. In case 2, there was no obvious discomfort. The lesion was located in the middle part of left tibia. Ct showed that the intramedullary boundary was not clear and the density was uneven. Histologically, round or polygonal cells were scattered or clustered in mature adipose tissue, rich in cytoplasm, containing many small lipid droplets, and rich in parenchyma. No abnormal bone trabeculae were found in the medullary cavity. Immunophenotype: UCP1 / S-100 cells were all positive for CKpan-CD68 and Calcitonin. PRLR was negative and no recurrence was found in the patients after one year follow-up. Conclusion Brown adipocyte proliferation is rarely reported in the medullary cavity. After operation, 18 F-FDG PET/CT scan should be used to differentiate tumor patients from brown adipose tissue.
【作者单位】： 安徽省池州市人民医院病理科;安徽省池州市人民医院骨科;
【分类号】：R551.3
【正文快照】： 棕色脂肪组织(brown adipose tissue,BAT)主要见于婴幼儿和儿童,分布于肩胛间区、腋窝、颈后部(血管和肌肉的周围)、肺门、纵隔和腹腔内(特别是肾、胰和脾周围),随着年龄增长而逐渐消失。采用18F-FDG PET/CT扫描成人AT,发现在颈部、锁骨上区、脊柱两侧、纵隔、肾周及肾上腺等，

本文编号：1484006