远隔缺血后适应对急性心肌梗死再灌注治疗患者血小板功能的影响

发布时间：2018-02-03 07:00

本文关键词： 心肌梗死血小板活化缺血后适应　出处：《重庆医学》2017年36期 　论文类型：期刊论文

【摘要】：目的探讨远隔缺血后适应(RIPostC)对急性心肌梗死再灌注治疗患者血小板功能的影响。方法入组2015年6月至2016年7月该院71名急性心肌梗死患者,均接受再灌注治疗。患者分为两组:处理组,接受RIPostC;对照组,接受假RIPostC。在经皮冠状动脉介入术(PCI)之前、RIPostC后即刻、PCI术后24h、PCI后48h采集患者的静脉血样,用流式细胞仪检测血小板活化指标CD62P和PAC-1,和血小板凋亡指标线粒体跨膜电位(ΔΨm)。结果处理组PCI术后24h血小板表面CD62P的表达明显低于对照组(P0.05),而在其他时间点两组差异无统计学意义(P0.05);两组血小板PAC-1表达在各个时间点差异无统计学意义(P0.05);两组患者血小板ΔΨm在各时间点差异也无统计学意义(P0.05)。结论 RIPostC能一定程度降低急性心肌梗死患者血小板的活化,不引起血小板早期凋亡。
[Abstract]:Objective to investigate the adaptation of RIPostC after distant ischemia. Methods from June 2015 to July 2016, 71 patients with acute myocardial infarction were enrolled. Patients were divided into two groups: treatment group, receiving RI PostC; In the control group, the venous blood samples were collected immediately after PCI 24 hours after PCI and 48 hours after PCI. Platelet activation indexes (CD62P and PAC-1) were detected by flow cytometry. Results the expression of CD62P on platelet surface in the treatment group was significantly lower than that in the control group 24 hours after the operation (P 0.05). However, there was no significant difference between the two groups at other time points (P 0.05). There was no significant difference in platelet PAC-1 expression between the two groups at different time points (P 0.05). There was no significant difference in 螖蠄 m between the two groups at different time points. Conclusion RIPostC can reduce platelet activation in patients with acute myocardial infarction to some extent. Early apoptosis of platelets was not induced.
【作者单位】：苏州大学附属第一医院心内科;
【基金】：国家自然科学基金资助项目(81400200)
【分类号】：R542.22
【正文快照】： 急性心肌梗死最重要的治疗方法是尽快恢复心肌的血液再灌注,但是再灌注治疗有时候会引起组织细胞更大的损伤,这种现象称之为缺血再灌注损伤[1]。既往研究表明,远隔器官或组织的短暂性缺血能够减少急性心肌梗死患者的心肌损伤,这种现象称远隔缺血适应。远隔缺血适应包括:远隔缺

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