心肌梗死患者血清低密度脂蛋白亚组分及与临床生物化学指标的相关性

发布时间：2018-02-04 16:55

本文关键词： 急性心肌梗死陈旧性心肌梗死低密度脂蛋白亚组分总胆固醇载脂蛋白B 肌酸激酶同工酶心肌肌钙蛋白T　出处：《中国动脉硬化杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的探讨心肌梗死患者血清低密度脂蛋白(LDL)亚组分的分布特征并分析其与急性心肌梗死、陈旧性心肌梗死患者血清临床生物化学指标的相关性。方法采集并筛选14例急性心肌梗死患者、24例陈旧性心肌梗死患者和19例健康体检者的新鲜血清,采用Lipoprint脂蛋白亚类分析系统检测血清LDL亚组分组成和含量。结果急性心肌梗死和陈旧性心肌梗死患者血清LDL平均粒径、I-LDL含量和百分比显著降低(P0.01),小LDL(S-LDL)含量和百分比显著升高(P0.01);从急性心肌梗死到陈旧性心肌梗死血清S-LDL尤其是LDL5C、LDL6C、LDL7C与血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、载脂蛋白B(Apo B)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白T(c Tn T)的相关性发生了显著性变化。结论 LDL粒径的降低,S-LDL含量与百分比的升高,较LDLC浓度的单独升高对心肌梗死患者的精准检测和诊断有非常重要的指导意义,血清LDL5C、LDL6C、LDL7C与临床生物化学指标相关性的检测对临床诊断心肌梗死以及鉴别诊断急性心肌梗死、陈旧性心肌梗死有极大的辅助诊断价值。
[Abstract]:Objective to investigate the distribution of low density lipoprotein (LDL) subfractions in patients with myocardial infarction (MI) and to analyze its relationship with acute myocardial infarction (AMI). Methods fresh serum samples from 14 patients with acute myocardial infarction (AMI) and 24 patients with old myocardial infarction (AMI) and 19 healthy controls were collected and screened. Lipoprint lipoprotein subclass analysis system was used to detect the composition and content of serum LDL subcomponents. Results the mean diameter of serum LDL was measured in patients with acute myocardial infarction and old myocardial infarction. The content and percentage of I-LDL decreased significantly (P 0.01), and the content and percentage of small LDL S-LDL increased significantly (P 0.01). From acute myocardial infarction to old myocardial infarction, serum S-LDL, especially LDL5CU LDL6CnLDL7C and serum total cholesterol (TCN), low density lipoprotein cholesterol (LDLC). The correlation between apolipoprotein (apo), creatine kinase isoenzyme (CK-MBN) and cardiac troponin (Tc Tn T) was significantly changed. Conclusion the particle size of LDL decreases. The increase of S-LDL content and percentage is very important to the accurate detection and diagnosis of myocardial infarction patients compared with the LDLC concentration alone. The serum LDL5CnLDL6C is very important. The detection of the correlation between LDL7C and clinical biochemical indexes is of great value in the diagnosis of myocardial infarction and the differential diagnosis of acute myocardial infarction and old myocardial infarction.
【作者单位】：辽宁省糖脂代谢研究重点实验室大连大学生命科学与技术学院;
【基金】：国家自然科学基金项目资助(81673494)
【分类号】：R446.1;R542.22
【正文快照】： 心肌梗死(myocardial infarction,MI)是冠状动脉粥样硬化性心脏病患者一支或多支血管管腔狭窄而侧支循环未及时充分建立,心肌出现严重持久的缺血缺氧而引起,可导致心源性休克甚至猝死。急性心肌梗死(acute myocardial infarction,AMI)是指由于冠状动脉供血急剧减少或中断,引起

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