蒲肯野纤维与室性心律失常

发布时间：2018-02-09 13:15

本文关键词： 蒲肯野纤维室性心律失常离子通道导管消融　出处：《临床心血管病杂志》2017年03期 　论文类型：期刊论文

【摘要】：心脏蒲肯野纤维是由蒲肯野细胞形成的纤维状网样结构,与房室束相连结,广泛分布于心内膜,在电冲动向心室肌的快速传播过程中起着重要的作用,使得左右心室快速同步激动。近年来的研究表明蒲肯野纤维好发心律失常,这主要是由于其解剖的复杂性和独特的细胞超微结构、电生理特性以及兴奋-收缩偶联的模式所导致的。蒲肯野纤维不仅可发生自律性和触发性心律失常,还可以发生折返性心律失常。无论是在结构性心脏病患者,还是在心脏结构正常的患者,蒲肯野纤维起源的触发灶经常可诱发心室颤动。另外,临床上许多单形性室性心动过速(室速)以蒲肯野纤维为折返环。对于蒲肯野纤维相关的单形性或多形性室性心律失常,以异常蒲肯野电位为靶点的导管消融往往十分有效。
[Abstract]:Cardiac Purkinje fiber is formed by the Purkinje cell fibrous network like structure, coupled with widely distributed in atrioventricular bundle, endocardium, plays an important role in the rapid propagation trend of electric impulse ventricular muscle in the left and right ventricular rapid synchronization excited. Recent studies have shown that primary cardiac Purkinje fiber wrong, this is mainly due to its unique anatomical complexity and cell ultrastructure, electrophysiological characteristics and excitation contraction coupling mode caused by Purkinje fiber not only can occur self-discipline and trigger arrhythmias can also occur reentrant arrhythmias. Both in patients with structural heart disease, or in the the cardiac structure in patients with normal Purkinje fiber origin often triggers can induce ventricular fibrillation. In addition, many clinical monomorphic ventricular tachycardia (VT) in Purkinje fiber reentrant ring. For Monomorphic or polymorphic ventricular arrhythmias associated with Purkinje fiber, abnormal Purkinje potential target ablation catheter is often very effective.

【作者单位】：上海交通大学医学院附属新华医院心内科;
【分类号】：R541.7

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