老年冠心病患者血清同型半胱氨酸、一氧化氮及内皮素的水平变化及意义

发布时间：2018-02-10 17:17

本文关键词： 冠心病同型半胱氨酸一氧化氮内皮素心血管事件　出处：《中国老年学杂志》2017年10期 　论文类型：期刊论文

【摘要】：目的研究老年冠心病(CHD)患者血清同型半胱氨酸(HCY)、一氧化氮(NO)及内皮素(ET)的水平及意义。方法选取100例CHD患者均接受冠状动脉造影检查及Gensini评分,检测HCY、NO及ET水平。患者接受12个月的随访,分析随访期间患者发生心血管事件的危险因素,分别评价Gensini评分、HCY、NO及ET对心血管事件的预测价值。结果 15例CHD患者发生心血管事件,Gensini评分、HCY、NO及ET是其危险因素(P0.05)。ROC曲线分析:Gensini曲线下面积为0.795,临界值为58.5分,敏感度为86.67%,特异度为96.47%;HCY分别为0.722、19.51μmol/L、86.67%及94.12%;ET分别为0.668,45.59 pg/ml,80.00%,89.41%;NO分别为0.599,61.63μmol/L,66.67%及82.35%。结论老年CHD患者血清HCY及ET升高,NO降低,上述指标对CHD患者12个月内的心血管事件具有提示意义。
[Abstract]:Objective to study the level and significance of serum homocysteine homocysteine nitric oxide (no) and endothelin (et) in elderly patients with coronary heart disease (CHD). Methods 100 patients with CHD received coronary angiography and Gensini score. The levels of HCYN and et were measured. The patients were followed up for 12 months to analyze the risk factors of cardiovascular events. Results HCYN and et were the risk factors for predicting cardiovascular events in 15 patients with CHD. Results the area under the 1: Gensini curve was 0. 795 and the critical value was 58. 5. The sensitivity was 86.67, the specificity was 96.470.The specificity of HCY was 0.722 ~ 19.51 渭 mol / L, 86.67% and 94.1212 ~ (-1) et were 0.66845.59 pgml / L, 80.0089 路ml ~ (-1) and 0.599 渭 mol / L ~ (66.67%) and 82.35 渭 mol / L ~ (-1), respectively. Conclusion the serum HCY and et increased in the elderly patients with CHD were lower than those in the control group, and the above indexes may be useful for cardiovascular events in the patients with CHD within 12 months.
【作者单位】：河北医科大学第二医院检验科;
【基金】：国家高技术研究发展计划(863计划)子课题(2014AA022304) 河北省卫生厅医学科学研究课题计划(20130466)
【分类号】：R541.4

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