让生物起搏梦想照进现实——再建心脏房室传导的策略思考

发布时间：2018-02-19 23:20

本文关键词： 生物心脏起搏器房室传导阻滞组织工程化心传导束传导速度细胞移植　出处：《第二军医大学学报》2017年07期 　论文类型：期刊论文

【摘要】：完全性房室传导阻滞是各种心脏病的重要并发症,生物心脏起搏是近年来其治疗研究的热点。本文通过分析目前生物起搏的临床应用所面临的瓶颈和问题,结合笔者的研究实践,就再建心脏房室传导通路这一课题提出如下思考:(1)组织工程化心传导束(ECT)是生物起搏治疗房室传导阻滞策略中一种较为理想的方式;(2)非基因改造成体干细胞诱导为起搏细胞或传导细胞,能够使生物起搏和ECT治疗房室传导阻滞的临床推广应用变得容易;(3)采用ECT实现生理性房室传导及临床应用,必须对其进行传导速度调控;(4)须围绕"ECT组织细胞类型及缝隙连接蛋白表达"这一关键点,设计传导速度调控的可行性方案。相信随着ECT研究工作的深入开展,ECT必将对生物起搏治疗的临床转化产生重要影响。
[Abstract]:Complete atrioventricular block (AVB) is an important complication of various heart diseases. Biological cardiac pacing is a hot topic in recent years. Combined with the author's research practice, On the topic of reconstructing the atrioventricular conduction pathway: 1) tissue engineered cardiac conduction bundle (ECT) is an ideal method for the treatment of atrioventricular conduction block by biological pacing (n = 2) induced by non-genetically modified adult stem cells. For pacemaker cells or conduction cells, It can make it easy to popularize the clinical application of biological pacing and ECT in the treatment of atrioventricular block (AVB). Using ECT to realize physiologic atrioventricular conduction and clinical application. It must be controlled by conduction velocity.) it should be centered around the key point of "the type of ECT tissue cells and the expression of gap junction protein". It is believed that with the further development of ECT research, it will have an important impact on the clinical transformation of biological pacing therapy.
【作者单位】：第二军医大学再生医学研究中心;
【基金】：国家自然科学基金(81371708,81271717) 上海市自然科学基金(09ZR1439300) 军队医学科技“十二五”规划课题(CWS12J087)~~
【分类号】：R541.7

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