丹红注射液配合调脂治疗对冠心病心绞痛患者血管内皮功能的影响

发布时间：2018-02-21 00:41

本文关键词： 丹红注射液调脂冠心病心绞痛血脂血管内皮功能　出处：《中华中医药学刊》2017年09期 　论文类型：期刊论文

【摘要】：目的:探索丹红注射液配合调脂治疗冠心病心绞痛的临床疗效及对患者血管内皮功能的影响。方法:94例冠心病心绞痛患者纳入临床研究,按照就诊时间编号并依据单双号分为观察组和对照组,各47例。两组均接受冠心病心绞痛基础治疗,另外对照组患者进行调脂治疗,观察组患者应用丹红注射液配合调脂治疗,比较临床疗效、治疗前后血脂水平和血管内皮功能差异以及不良反应的发生情况。结果:观察组治疗总有效率为93.62%,对照组治疗总有效率为74.47%。两组数据比较差异有统计学意义(χ2=8.778,P0.05)。经治疗后,观察组患者血脂指标TC(4.76±0.84)mmol/L、TG(1.69±0.27)mmol/L、LDL-C(2.56±0.73)mmol/L与治疗前比较均明显降低(t=8.341,7.447,6.708,P0.05),与对照组差异有统计学意义(t=8.462,7.309,6.209,P0.05)。经治疗后观察组患者ET(62.78±5.14)pg/m L与治疗前比较明显降低(P0.05),NO(69.24±8.16)μmol/L、FMD(14.57±2.09)%与治疗前比较明显升高(t=8.478,7.698,7.899,P0.05),与对照组差异均有统计学意义(t=7.677,6.620,6.455,P0.05)。治疗期间,观察组不良反应发生率为10.64%;对照组不良反应发生率为12.77%,两组数据比较差异无统计学意义(χ2=1.887,P0.05)。结论:丹红注射液配合调脂治疗对冠心病心绞痛的治疗效果显著,能够有效缓解患者心绞痛症状,降低血脂水平,改善血管内皮功能,且无明显不良反应发生,有应用和推广价值。
[Abstract]:Objective: to explore the clinical effect of Danhong injection combined with lipid regulation on angina pectoris of coronary heart disease and its effect on vascular endothelial function. Methods: 94 patients with angina pectoris of coronary heart disease were included in the clinical study. According to the number of visit time and according to the single and even number, the two groups were divided into observation group and control group, each with 47 cases. Both groups received basic treatment of coronary heart disease angina pectoris. In addition, the patients in the control group were treated with lipid-regulating therapy. To compare the clinical efficacy, Results: the total effective rate of treatment in the observation group was 93.622.The total effective rate in the control group was 74.47.The difference between the two groups was statistically significant (蠂 ~ 2 / 8.778) (P 0.05). The blood lipid index (TC(4.76 卤0.84mmol / L) of the observation group was 1.69 卤0.27mmol / L LDL-C 2.56 卤0.73 mmol / L respectively. Compared with the control group, the blood lipid index of the observation group was significantly lower than that of the control group. The difference was statistically significant between the observation group and the control group (t 8.4627.3096.209g / L, P 0.05). After treatment, the ET(62.78 卤5.14g / mL / L of the observed group was significantly lower than that of the pre-treatment group (P 0.05N / L, P 0.05 9.24 卤8.16) 渭 mol / L P 0.05%, and that of the observation group was significantly higher than that of the control group (8.88697.87.87.89 P 0.05 P 0.05), and significantly lower than that of the control group (P < 0.01), and significantly lower than that of the control group (P < 0.05), and compared with that of the control group (P < 0.05). After treatment, the ET(62.78 卤5.14 渭 mol / L LDL-C < 2.56 卤0.73 卤8.16 渭 mol / L / L was significantly lower than that of the control group. The difference between the two groups was statistically significant (P 0.05). The incidence of adverse reactions in the observation group was 10.64, and that in the control group was 12.77. There was no significant difference between the two groups (蠂 ~ 2 / 1.887, P 0.050.Conclusion: Danhong injection combined with lipid-regulating therapy has a significant effect on angina pectoris of coronary heart disease. It can effectively alleviate the symptoms of angina pectoris, reduce the level of blood lipid, improve vascular endothelial function, and there is no obvious adverse reaction, which has application and promotion value.
【作者单位】：海南医学院第二附属医院急诊科;
【基金】：海南省自然科学基金项目(20158316)
【分类号】：R541.4

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