益血生胶囊联合利可君片治疗慢性乙型肝炎合并白细胞减少症的临床研究

发布时间：2018-02-21 10:30

本文关键词： 慢性乙型肝炎白细胞减少症益血生胶囊利血生片　出处：《中华中医药学刊》2017年10期 　论文类型：期刊论文

【摘要】：目的:观察益血生胶囊联合利血生片治疗慢性乙型肝炎合并白细胞减少症的临床效果。方法:选取医院2015年3月—2016年3月收治的70例慢性乙型肝炎合并白细胞减少症患者,按照随机数字表法分为观察组与对照组,每组35例,对照组服用利血生片治疗,观察组采用益血生胶囊联合利血生片治疗,比较两组患者临床疗效及对慢性乙型肝炎合并白细胞减少症的影响。结果:观察组患者治疗总有效率高达94.29%,较对照组的71.43%明显提高,差异具有统计学意义(P0.05);观察组的ALT复常例数和复常率、HBV-DNA转阴例数和转阴率显著高于对照组,差异有统计学意义(P0.05);治疗后观察组患者外周血白细胞计数水平显著高于对照组(P0.05);两组患者未见明显不良反应。结论:针对慢性乙型肝炎合并白细胞减少症患者,采用益血生胶囊联合利血生片治疗,有利于缓解临床症状,增加外周白细胞计数水平,减轻患者痛苦,不良反应少,安全可靠性高,具有较高的临床应用价值。
[Abstract]:Objective: to observe the clinical effect of Yixusheng capsule combined with Lixuesheng tablet in the treatment of chronic hepatitis B with leukopenia. Methods: from March 2015 to March 2016, 70 patients with chronic hepatitis B complicated with leukopenia were selected. According to the method of random number table, 35 cases in each group were divided into observation group and control group. The control group was treated with Lixuesheng tablet, and the observation group was treated with Yixuesheng capsule combined with Lixuesheng tablet. Results: the total effective rate of treatment in the observation group was 94.29, which was significantly higher than that in the control group (71.43%). The number and rate of ALT complex cases and HBV-DNA negative conversion in the observation group were significantly higher than those in the control group, the difference was statistically significant (P 0.05), and the number and rate of HBV-DNA negative conversion in the observation group were significantly higher than those in the control group. The difference was statistically significant (P 0.05), the level of peripheral blood leukocyte count in the observation group was significantly higher than that in the control group (P 0.05), and there was no significant adverse reaction between the two groups. Conclusion: for the patients with chronic hepatitis B and leukopenia, there is no significant adverse reaction in the two groups. The combination of Yixuesheng capsule and Lixuesheng tablet is beneficial to relieve clinical symptoms, increase peripheral white blood cell count, alleviate the pain of patients, have less adverse reactions, have high safety and reliability, and have high clinical application value.
【作者单位】：浙江衢化医院;
【分类号】：R512.62;R557.1

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